Raw Materials CAS 41100-52-1 Memantine Hydrochloride Memantine HCl

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >98%
• Model NO.: Memantine
• Name: Memantine
• Mf: C12h22cln
• CAS: 41100-52-1
• Transport Package: Drum
• Specification: 99%
• Trademark: HS
• Origin: China
• HS Code: 2904201000
• Production Capacity: 100000

Product Description

Product Name:Memantine HCl
Trade Name: Namenda
CAS No.:41100-52-1
Molecular Formula:C12H22ClN
Molecular Weight: 215.76g/mol
Purity : 99.5% HPLC
Appearance:  White powder
Standard Packing : 100g,1kg,25kg
Typical use :Alzheimer disease
Shelf Life :2 years
Storage:Refrigerator away from light

Application

It is believed that too much stimulation of nerve cells by glutamate may be responsible for the degeneration of nerves that occurs in some neurological diseases such as Alzheimer's disease. Glutamate is produced and released by nerve cells in the brain. The released glutamate then travels to nearby nerve cells where it attaches to a receptor on the surface of the cells called the N-methyl-D-aspartate (NMDA) receptor.

Memantine HCL blocks this receptor and thereby decreases the effects of glutamate. It is thought that by blocking the NMDA receptor and the effects of glutamate, memantine may protect nerve cells from excess stimulation by glutamate.

What is Memantine?
Memantine hydrochloride is a raw material. It should be prescribed by experienced doctors in the diagnosis and treatment of Alzheimer's dementia and guided by patients. Treatment can only begin when there are caregivers around the patient who regularly supervise the patient's medication. Dementia should be diagnosed in accordance with current diagnostic criteria and guidelines.

Description
Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Treatment should only be continued if beneficial effects are seen. It is taken by mouth.
Memantine was approved for medical use in the United States in 2003. It is available as a generic medication. In 2017, it was the 149th most commonly prescribed medication in the United States, with more than four million prescriptions

 

Memantine Benefits
Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer's disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European.
The development of Alzheimer's disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity.
Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs).
Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington's disease, ALS and movement disorders, among other. 

Medical Use   
Memantine is used to treat moderate-to-severe Alzheimer's disease, especially for people who are intolerant of or have a contraindication to AChE (acetylcholinesterase) inhibitors.One guideline recommends memantine or an AChE inhibitor be considered in people in the early-to-mid stage of dementia.

Memantine has been associated with a modest improvement; with small positive effects on cognition, mood, behavior, and the ability to perform daily activities in moderate-to-severe Alzheimer's disease. There does not appear to be any benefit in mild disease.

Memantine when added to donepezil in those with moderate-to-severe dementia resulted in "limited improvements" in a 2017 review. The UK National Institute of Clinical Excellence (NICE) issued guidance in 2018 recommending consideration of the combination of memantine with donepezil in those with moderate-to-severe dementia. Effects in autism are unclear. Recent scientific journal reports are showing guarded promise with severe obsessive compulsive disorder.

Related Products : 

Below are examples of the drugs most commonly prescribed to prevent or slow the development of AD symptoms. How effective these drugs are can vary from person to person. All of these drugs also become less effective over time as AD becomes gradually worse.
Donepezil (Aricept): This drug is used to delay or slow the symptoms of mild, moderate, and severe AD. It comes in a tablet or disintegrating tablet.
Galantamine (Razadyne): This drug is used to prevent or slow the symptoms of mild to moderate AD. It comes as a tablet, extended-release capsule, or oral solution (liquid).
Memantine (Namenda): This drug is sometimes given with Aricept, Exelon, or Razadyne. It's used to delay or slow the symptoms of moderate to severe AD. It comes in a tablet, extended-release capsule, and oral solution.
Rivastigmine (Exelon): This drug is used to prevent or slow the symptoms of mild to moderate AD. It comes in a capsule or extended-release transdermal patch.
Memantine extended-release and donepezil (Namzaric): This drug capsule is used to treat moderate to severe AD. It's prescribed for certain people who take donepezil and who have not had bad reactions to the ingredients. No evidence suggests that it prevents or slows underlying disease process.

Item	Requirements	Test Results
appearance	White or almost white crystalline powder	White crystalline powder
Identification	IR	Comply
Related substance	1-methyladamantane ≤0.3% 1,3,5 -trimethyladamantane ≤0.3% Unknow impuritiy     ≤0.1% Total impurity ≤0.5%	0.13% 0.14% <0.1% <0.4%
Residue on ignition	≤0.1%	0.06%
Heavy matal	≤10ppm	<10ppm
Loss on drying	≤0.5%	0.29%
Assay	98.5-101.0%	99.13%
Residual Solvents	Ethyl Acetate: ≤0.5% Ethanol: ≤0.5%	0.08% 0.12%
PH	4.5-5.5	5.3
Microbial Limits	Max 5*102 aerobes and fungl per 1g  E. Coli: Negative Salmonella: Negative	Pass
Size of distributed particles	Pass 100μ m	Conforms
Conclusion	Meet the requirements