CAS 81103-11-9 Biaxin Aclarubicin Aclacinomycin Clarithromycin

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >96%
• Model NO.: clarithromycin
• Name: Clarithromycin
• Mf: C38h69no13
• CAS: 81103-11-9
• Whtsa[PP: 86 152 029 61574
• Transport Package: Drum
• Specification: 99%
• Trademark: HS
• Origin: China
• HS Code: 2904201000
• Production Capacity: 100000

Product Description

Product Name	Clarithromycin
CAS number	81103-11-9
Molecular formula	C38H69NO13
Molecular weight	704.95
Appearance	White crystalline powder
Boiling point	86ºC at 760mmHg
Flash Point	>110ºC
Relative density	1.14 g/cm³

Clarithromycin, sold under the brand name Biaxin, is an antibiotic used to treat various bacterial infections. This includes strep throat, pneumonia, skin infections, H. pylori infection, and Lyme disease, among others. Clarithromycin can be taken by mouth as a pill or liquid. Common side effects include nausea, vomiting, headaches, and diarrhea. Severe allergic reactions are rare. Liver problems have been reported. It may cause harm if taken during pregnancy. It is in the macrolide class and works by stopping the making of protein by some bacteria. Clarithromycin was developed in 1980. It is on the World Health Organization's List of Essential Medicines the most important medications needed in a basic health system. Clarithromycin is available as a generic medication. The wholesale cost in the developing world is between 0.13 and 0.79 USD per dose. In the United States it is moderately expensive at 50 to 100 USD for a course of treatment. It is made from erythromycin and is chemically known as 6-O-methylerythromycin.

Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.Target: Antibacterial; CYP3A4Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. Clarithromycin prevents bacteria from growing by interfering with their protein synthesis. It binds to the subunit 50S of the bacterial ribosome and thus inhibits the translation of peptides. Clarithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain Gram-negative bacteria, particularly Legionella pneumophila. Besides this bacteriostatic effect, clarithromycin also has bactericidal effect on certain strains, such as Haemophilus influenzae, Streptococcus pneumoniae and Neisseria gonorrhoeae. Clarithromycin is a CYP3A4 inhibitor. Even low doses of the cytochrome P4503A4 (CYP3A4) inhibitor clarithromycin increase the plasma concentrations and effects of repaglinide. Concomitant use of clarithromycin or other potent inhibitors of CYP3A4 with repaglinide may enhance its blood glucose-lowering effect and increase the risk of hypoglycemia.
Clarithromycin is mainly used for caused by sensitive bacteria upper and lower respiratory tract, including tonsil inflammation, sore throat, deputy sinusitis, bronchitis, pneumonia, etc, skin, soft tissue infection, pus furuncle, erysipelas, folliculitis, wound infection and so on, curative effect and other large ring lactone class similar. The goods can also be used to chlamydia trachomatis or dissolved ureaplasma urealyticum reproduction caused by urinary tract infection, AIDS patients with atypical mycobacteria infection.

 

TEST ITEM	SPECIFICAION	RESULTS
Description	White or almost white crystalline powder	Complies
Solubility	Practically insoluble in water, Soluble in acetone and in ethylene slightly soluble in methanol.	Complies
Identification IR spectrum	Conforms to claritinomycin RS	Complies
Specific rotation	Between -89°and -95°	-90.0°
Crystallinity	Meets the requirement	Meets the requirement
pH	Between 7.5and 10.0	8.58
Water	Not more than 2.0%	0.64%
Residue on ignitions	Not more than 0.3%	Complies
Assay	99.0%	99.8%