Factory supply 99% CAS 50-01-1 High Purity Guanidine Hydrochloride powder
| Product name |
Guanidine hydrochloride |
| Cas No. |
50-01-1 |
| Molecular Formula |
CH6ClN3 |
| Appearance |
White crystalline powder |
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH.It is found in the urine as a normal product of protein metabolism.It is also used in laboratory research as a protein denaturant.It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
Guanidine hydrochloride can break the hydrogen bond in protein structure, which increases the solubility of non-polar molecules including amino acid side chains, and reduces hydrophobic interaction. Urea can also penetrate into protein molecules and influence the dense accumulation of protein molecules. In addition, detergents, organic solvents, heavy metals, heat, mechanical force, freezing, ultrasound, high pressure, radiation and so on can cause denaturation of proteins. These denaturations do not destroy the covalent bonds of proteins, but only involve the destruction of secondary bonds such as hydrogen bonds, salt bonds, hydrophobic interactions and van der Waals interactions. Some denatured proteins can automatically return to their natural state when the denaturing factors are removed. This phenomenon is called renaturation, which is refolding in the study of protein folding.
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