Pharmaceutical Chemical CAS 13292-46-1 Powder Antibiotic Rifampicin

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >96%
• Model NO.: rifampicin
• Name: Rifampicin
• Mf: C43h58n4o12
• CAS: 13292-46-1
• Transport Package: Drum
• Specification: 99%
• Trademark: HS
• Origin: China
• HS Code: 2904201000
• Production Capacity: 100000

Product Description

Name: Rifampicin
Synonyms: 3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin;3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV;5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-(N-(4-methyl-1-piperazinyl)formimidoyl)-2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione 21-acetate;8-(4-Methylpiperazinyliminomethyl) rifamycin SV;
CAS Registry number: 13292-46-1
EINECS:236-312-0
Molecular Formula: C43H58N4O12
Boiling Point: 1004.42 °C at 760 mmHg
Flash Point: 561.253 °C
Density: 1.34 g/cm3
Appearance: Red to orange crystalline solid
Usage: Semisynthetic antibiotic. Antibacerial (tuberculostatic)
Rifampin of rifamycin class semisynthetic broad-spectrum antibiotic, for a variety of pathogenic microorganisms. Antibacterial activity. The drug for mycobacterium tuberculosis and part of the mycobacterium tuberculosis (including leprosy mycobacteria, etc.) both inside and outside the host cells have obvious antiseptic effect. Rifampicin on aerobic gram positive bacteria have good antibacterial effect, including staphylococcus enzyme production strains and methicillin resistant strains, streptococcus pneumoniae, streptococcus, enterococcus other genera, listeria monocytogenes, bacillus anthracis, gas capsule bacillus, corynebacterium diphtheriae, anaerobic bacteria, etc. For aerobic gram-negative bacteria such as neisseria gonorrhoeae, h. influenzae, gonorrhea neisseria gonorrhoeae has high antibacterial activity. Rifampin of legionella bacteria effect also good, for chlamydia trachomatis, venereal disease is lymphatic granulation is swollen, psittacosis pathogens are inhibition, etc. Bacteria have cross resistance to rifamycin class antibiotics. Rifampicin and dependent on DNA, RNA polymerase beta subunit solid combination, inhibit bacterial RNA synthesis, prevent the enzyme connected with DNA, thereby blocking process of RNA transcription, DNA and protein synthesis.

Rifampicin Application:

1. the product used in combination with other anti-TB drugs initial treatment and retreatment of various tuberculosis, including tuberculous meningitis treatment.

 

2. the product used in combination with other drugs leprosy, non-tuberculous mycobacterial infections.

 

3. The goods and vancomycin (intravenous) can be combined for methicillin resistant Staphylococcus aureus caused serious infections. Rifampicin and erythromycin joint programs can be used to Legionella serious infections.

 

4. for asymptomatic carriers of Neisseria meningitidis to eliminate Neisseria meningitidis nasopharynx; but not for Neisseria meningitidis infection.

 

Packing:

Tests	Specifications	Results
Appearance	A bright-red, crystalline powder	Conforms
Identification	A,B,C	Conforms
PH	4.5~6.5	5.5
Loss on drying	Not more than 1.0%	0.8%
Sulphated ash	Not more than 0.1%	0.06%
Heavy metals	Not more than 20ppm	0.08ppm
Bulk density (g/ml)	0.5	0.52
Related substances Rifampicin quinone Any other impurity Total impurities	Not more than 1.5% Not more than 1.0% Not more than 3.5%	0.5% 0.7% 2.1%
Assay( 0n dry basis)	97.0%~102.0%	99.3%