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Name : 5-Fluorouracil
Shape : White crystalline powder
This product is a pyrimidine fluoride, belongs to the anti-metabolic anti-tumor drug, can inhibit thymine nucleotide synthetase, block the conversion of deoxypyrimidine nucleotide into thymine nucleoside nucleus, interfere with DNA synthesis.It also inhibits the synthesis of RNA.
Clinical use for colon cancer, rectal cancer, stomach cancer, breast cancer, ovarian cancer, chorioepithelial cancer, malignant mole, head and neck squamous cell cancer, skin cancer, liver cancer, bladder cancer, etc.
The oral absorption of this product is incomplete and unpredictable, so it is injected and rapidly distributed to all tissues of the body: cerebrospinal fluid and tumor tissue after intravenous injection.As mentioned above, 5-Fu is only converted into active nucleotide metabolites in the body to act.Metabolic degradation can occur in many tissues, especially in the liver.Under the action of dihydropyrimidine reductase in liver, intestinal mucosa and other tissues, 5-Fu is reduced to 5-fluoro-5, 6-dihydrouracil and inactivated.
Name | CAS | molecular | density |
5-Fluorouracil | C20H21F3N4O | 1.292 |