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Chloroquine diphosphate is the phosphate salt of chloroquine, compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.
English name Chloroquine Phosphate Chemical formula C18H32ClN3O8P2 Molecular weight 515.87 CAS accession number 50-63-5 EINECS accession number 200-055-2 Melting point 193 to 196 ºC (decomposition) Boiling point 460.6 ºC Appearance White crystalline powder, odorless, gradient color when exposed to light |