Anti-Depression CAS 56296-78-7 Fluoxetine HCl Hydrochloride Fluoxetine

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >98%
• Model NO.: fluoxetine
• Name: Fluoxetine HCl
• CAS: 56296-78-7
• Transport Package: Drum
• Specification: 99%
• Trademark: HS
• Origin: China
• HS Code: 2904201000
• Production Capacity: 100000

Product Description

Fluoxetine hydrochloride discovery of fluoxetine began at Eli Lilly in 1970 as a collaboration between Bryan Molloy and Robert Rathbun. Testing the physiological effects of these compounds in mice resulted in nisoxetine, a selective norepinephrine reuptake inhibitor currently widely used in biochemical experiments. This test which carried out by Jong-Sir Horng in May 1972, showed the compound later named fluoxetine to be the most strong and selective inhibitor of serotonin reuptake of the series. Two years later they had to issue a correction, admitting that the first SSRI was zimelidine developed by Arvid Carlsson and colleagues. In 1986, Fluoxetine made its appearance on the Belgian market and was approved for use by the FDA in the United States in December 1987. Fluoxetine was the fourth SSRI to make it to market, after zimelidine, indalpine and fluvoxamine. 

Introduction:

Fluoxetine was shown to be effective for depression in six-week-long double-blind controlled trials, where it also alleviated anxiety and improved sleep. Fluoxetine was better than placebo for the prevention of depression recurrence when the patients, who originally responded to fluoxetine, were treated for a further 38 weeks. Efficacy of fluoxetine for geriatric, as well as pediatric, depression was also demonstrated in placebo-controlled trials.

Research suggests that a significant part of the resistance to the SSRIs paroxetine (Paxil) and citalopram(Celexa) can be explained by the genetic variation of Pgp transporter. Paroxetine and citalopram, which are Pgp substrates, are actively transported from the brain by this protein. Fluoxetine is not a substrate of Pgp, and thus a switch from paroxetine or citalopram to fluoxetine may be beneficial to the nonresponders.

 

Application:

Fluoxetine is frequently used to treat major depression, obsessive compulsive disorder, bulimia nervosa,panic disorder, body dysmorphic disorder, premenstrual dysphoric disorder, and trichotillomania. Caution should be taken when using any SSRI for bipolar disorder as this can increase the likelihood of mania; however, fluoxetine can be used with an antipsychotic (such as quetiapine) for bipolar. It has also been used for cataplexy, obesity, and alcohol dependence,as well as binge eating disorder.

Appearance	White crystal	White crystal
Identification A:Infrared absorption B:Retention of time	A: Positive B: Positive	A: Complies B: Complies
Assay	98.0~101.5%	100.20%
Optical rotation	-0.05~+0.05	+0.01
Total impurity	≤0.5%	Complies%
3-methylaminol-l-phenylpropan-l-ol	≤0.25%	0.05%
N-methyl-3-phenylpropyl-l-amine	≤0.25%	0.05%
N-methyl-3-phenyl-3-(trifluoromet hylphenoxy)   propyl-l-amine	≤0.15%	0.03%
Other impurity	≤0.10%	Complies
Organic volatile impurity	Complies	Complies
Sulphated ash	≤0.1%	0.02%
Water	≤0.5%	0.20%
pH	4.5~6.5	5.70
Heavy metals	≤10ppm	Complies
Solubility	Colorless clear	Colorless clear
TVC	≤10 cfn/g	Complies
Mould and yeast	≤10 cfn/g	Complies
Conclusion: comply with the USP30/BP2002