| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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Product Name
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Oxytetracycline HCl |
|
Appearance
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White powder
|
|
Assay
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10%,20%,40% water soluble,98% fat-soluble Oxytetracycline HCl
|
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CAS No.
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2058-46-0 |
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Molecular Formula
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C22H25ClN2O9 |
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Molecular Weight
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533.356 |
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Melting point
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839.6ºC at 760 mmHg |
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Grade
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Food & Cosmetic & Medicine Grade
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Test Method
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HPLC
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Storage
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Store in cool and dry place,keep away from strong light.
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Shelf life
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2 years when properly stored.
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It is a broad spectrum antibiotic, and its antibacterial spectrum, antibacterial principle and application are basically the same as tetracycline. Many Rickettsiae, Mycoplasma, Chlamydia, spirochetes, amoebas and some Plasmodium species are also sensitive to this product. Enterococci are resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium SPP., Nocardia SPP., Vibrio SPP., Brucella SPP., Campylobacter SPP., Yersinia SPP. This product has certain antibacterial activity against gonococci and meningococci, but penicillin-resistant gonococci are also resistant to oxytetracycline. Due to the wide application of tetracycline for many years, the common clinical pathogens have serious resistance to tetracycline, including Staphylococcus and other Gram-positive bacteria and most gram-negative bacilli. Cross resistance exists among different varieties of tetracycline antibiotics. The mechanism of action of this product is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, inhibit the growth of peptide chain and affect the synthesis of bacterial protein. This product is slightly more effective than tetracycline against intestinal infections, including amoebic dysentery. There is close cross resistance with tetracycline.
| Item of Analysis | Specification | Results | Test Methods |
| Assay(on the anhydrous basis ) | 98%~101% | 99.20% | HPLC |
| Appearance | White powder | Conform | Visual |
| Identification | |||
| A: IR | Corresponds qualitatively to the reference | Complies | USP41-NF36 |
| B: Color Reaction | A blue color appears | Positive | USP41-NF36 |
| Water(KF) | ≤0.2% | 0.03% | USP41-NF36 |
| Residue on ignition | ≤0.1% | 0.02% | USP41-NF36 |
| Mesh size | Not less than 90% pass 80 mesh | Complies | 80 mesh screen |
| Residual Solvents | Ethanol ≤1000ppm | 18ppm | USP41-NF36 |
| Heavy metals | Inorganic arsenic ≤3μg/g | 0.06μg/g | USP41-NF36 |
| Total Hg ≤3μg/g | <0.01μg/g | USP41-NF36 | |
| Lead ≤1μg/g | 0.09μg/g | USP41-NF36 | |
| Chromatographic purity | Test 1: Coenzyme Q7,Q8,Q9,Q11 and related impurities:≤1.0% Test 2: 2Z isomer and related impurities:≤1.0% Test 1 & Test 2: ≤1.5% Test 3: The single related impurities≤0.3% |
0.37% 0.05% 0.42% 0.25% |
USP41-NF36 |
| Total Plate Count | ≤1000cfu/g | <10 cfu/g | USP41-NF36 |
| Yeast & Mold | ≤100cfu/g | <15 cfu/g | USP41-NF36 |
| E. Coli. | Negative | Negative | USP41-NF36 |
| Salmonelle | Negative | Negative | USP41-NF36 |
| S.aureus | Negative | Negative | USP41-NF36 |
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