| Customization: | Available |
|---|---|
| Varieties: | Parasite Disease Prevention Medicine |
| Component: | Chemical Synthetic Drugs |
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| Melting Point | 187ºC |
|---|---|
| Molecular Formula | C13H16N3NaO4S |
| Molecular Weight | 333.339 |
| Exact Mass | 333.075928 |
| PSA | 95.75000 |
| LogP | 1.50410 |
Metamizole (INN), or dipyrone, is an analgesic (pain reliever) and antipyretic (fever reducer). Metamizole sodium is marketed under various trade names, including Algozone, Algocalmin, Algopyrin, Analgin, Dipirona, Novalgin, Neo-Melubrina and Optalgin. Metamizole was first synthesized by the German companyHoechst AG (now part of Sanofi) in 1920, and its mass production started in 1922. It remained available worldwide until the 1970s, when it was linked with a small risk of causing agranulocytosis, a potentially fatal condition. Those results have been disputed in meta-analyses conducted in the 2000s.Regardless, several national medical authorities have withdrawn metamizole from the market altogether or have restricted it to be available only with a prescription, although it remains available over the counter in many countries.
Analgin (Metamizole Sodium Tablets), common Medicare prescription drugs. Compound aminopyrine and sodium sulfite combining soluble in water, antipyretic, analgesic effect than aminopyrine fast and strong.
Analgin is a non-steroidal antiinflammatory drug that potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX.
Function:
1.Pharmacological effects of anti-inflammatory role of strong and fast, but also has some anti-inflammatory anti-rheumatic effect on gastrointestinal smooth muscle spasm also have a
good antispasmodic effect.
2.Indications for antipyretic, analgesic, anti-rheumatic. Also used for intestinal spasms
and intestinal swelling gas embolism.
Application:
1.Analgin are used for the treatment of pains of different origin and variable intensity: Toothache, headache, arthralgia, neuralgia, myositis, mild to moderate visceral pain, high fever, not responding to other drugs.
2.Analgin injection is used in cases of acute and severe pain affter operations and traumas, pain associated with neoplastic diseases, colicky pain etc.
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Test |
Standards |
Results |
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Characteristics |
A white or almost white, crystalline powder , very soluble in water, soluble in alcohol |
A white , crystalline powder , very soluble in water, soluble in alcohol |
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Identification |
A:IR absorption |
Complies |
Complies |
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B,C,D: Chemical identification |
Complies |
Complies |
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Related substance |
Impurity C not more than 0.5% |
0.19% |
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Any other impurity not more than 0.2% |
0.07% |
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Total of all impurities not more than 0.5% |
0.24% |
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Appearance of solution |
Clear and not more intensely colored than reference solution BY6 |
Clear and Colorless |
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Acidity or alkalinity |
Complies |
Complies |
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Sulphates |
Not more than 0.1% |
Less than 0.1% |
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Heavy metals |
Not more than 20ppm |
Less than 10ppm |
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Loss on drying ( 105°C +/- 2°C) |
4.9%-5.3%
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5.0% |
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Assay |
99.0-101.0% (dried substance) |
99.6% |
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