High Quality CAS 53902-12-8 Tranilast

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Light-Yellow Crystal or Crys
• Purity: >99%
• Model NO.: Tranilast
• CAS: 53902-12-8
• Mf: C18h17no5
• MW: 327.33
• Grade: Phamaceutical Grade
• Melting Point: 153-154c
• Storage: Cool Dry Place
• Shelf Life: 24 Months
• Transport Package: 1kg/Bag, 25kg/Drum
• Specification: Tranilast
• Trademark: HNB
• Origin: China
• Production Capacity: 500kg/Month

Product Description

product Name	Tranilast
Molecular Formula	C18H17NO5
Molecular Weight	327.33
CAS Registry Number	53902-12-8
Melting point	153-154ºC
Boiling point	154.5°C
Refractive index	Keep in a cool, dry, dark location
Flash point	24 months when properly stored

Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial.
Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of
vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal
diseases.

Items	Specification
Appearance	Light yellow or light-yellow green crystal or crystalline powder
Assay	≥98.5%
Melting point	207-210°C
Identification:	1)It appears positive reaction 2)Maximum absorbability at 333nm Wavelength Minimum absorbability at 263nm Wavelength 3)Complies
Chloride	Conform
Relevant material	Conform
Loss on drying	≤0.5%
Residue on ignition	≤0.1%
Heavy metals	≤15ppm
Microbe limitation	Conform