| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Acetazolamide is an inhibitor of carbonic anhydrase. It also inhibits cell membrane water permeability via interaction with aquaporins.
| Product name | Acetazolamide |
| Formula | C4H6N4O3S2 |
| Molecular Weight | 222.26 |
| CAS No. | 59-66-5 |
| EINECS | 200-440-5 |
| Density | 1.744 g/cm3 |
| Melting Point | 256-261 °C |
| Solubility | <0.1 g/100 mL at 22 °C in water |
| Appearance | White to yellowish-white fine crystalline powder |
Common side effects include numbness, ringing in the ears, loss of appetite, vomiting, and sleepiness.It is not recommended in those with significant kidney problems, liver problems, or who are allergic to sulfonamides.Acetazolamide is in the diuretic and carbonic anhydrase inhibitor families of medication. It works by decreasing the amount of hydrogen ions and bicarbonate in the body.
It is used in the treatment of glaucoma, drug-induced edema, heart failure-induced edema, epilepsy and in reducing intraocular pressure after surgery. It has also been used in the treatment of mountain sickness,Ménière's disease, increased intracranial pressure and neuromuscular disorders.
In epilepsy, the main use of acetazolamide is in menstrual-related epilepsy and as an add on to other treatments in refractory epilepsy.It has been demonstrated in drug trials to relieve symptoms associated with dural ectasia in individuals with Marfan's Syndrome.A 2012 review and meta-analysis found that there was "limited supporting evidence" but that acetazolamide "may be considered" for the treatment of central (as opposed to obstructive) sleep apnea.
It has also been used to prevent methotrexate-induced kidney damage by alkalinalizing one's urine, hence speeding up methotrexate excretion by increasing its solubility in urine.
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Items |
Standard |
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Characteristics |
white to off white crystalline powder |
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Identification A. B. |
Positive reactions Positive reactions |
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sulfate |
400ppm max |
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water |
0.5% max |
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Residue on ignition |
0.1% max |
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Silver-reducing substances |
4.8ml min |
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Chloride |
140ppm max |
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Ordinary impurities |
1 max |
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Heavy metals |
20 ppm max |
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Organic volatile impurities |
Meet the requirements |
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Assay |
98.5% min |
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