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Name : Nifedipine
Shape : Light Yellow crystalline powder
Nifedipine can be used for the treatment of hypertension, angina pectoris and other diseases, in addition to the current clinical use of nifedipine in the treatment of urinary stone colic, children's nervous frequency of urination, bile colic and gastrointestinal cramps and other diseases.
1. Selectively inhibit calcium inflow of myocardial membrane, block excitation-contraction coupling of cardiomyocytes, weaken myocardial contractility, reduce myocardial energy and oxygen consumption, and directly protect cardiomyocytes by preventing calcium overload.
2. Inhibit excitation-contraction coupling of blood vessels, bronchus and uterine smooth muscle, dilate systemic blood vessels (including lung, liver, kidney, brain, femoral and mesenteric arteries) and coronary arteries. The mechanism of vascular smooth muscle expansion is complex
Nifedipine, also known as 1, 4-dihydro-2, 6-dimethyl-4 -(2-nitrophenyl)-3, 5-pyridine dicarboxylate, is a dihydropyridine calcium antagonist used for the prevention and treatment of coronary heart disease angina pectoris, especially variant angina pectoris and angina pectoris caused by coronary artery spasms.It has no adverse effect on respiratory function, so it is suitable for patients with angina pectoris suffering from respiratory obstructive diseases, and its efficacy is better than that of β-receptor antagonists.It is also applicable to various types of hypertension, and has a good effect on intractable and severe hypertension.Because it can reduce afterload, it also has a good effect on refractory congestive heart failure, and is suitable for long-term use.
Name | CAS | molecular | density |
Nifedipine | 21829-25-4 | C17H18N2O6 | 1.271 |