| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Prodcut name | Tetracycline hydrochloride |
| Synonyms | achromycin hydrochloride;alatet;qidtet;paltet;2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]-; |
| MOQ | 1KG |
| CAS | 64-75-5 |
| Appearance | Yellow powder |
| Molecular Formula | C22H25ClN2O8 |
| Molecular Weight | 480.896 |
| Assay | 99% |
| Application | Pharma grade |
| Packing | As per your request |
| Storage | Preserve in tight, light-resistant containers in a cool place |
| Remarks | NA |
| Custom synthesis | Available |
What isTetracycline?
Tetracycline hydrochloride is the hydrochloride form of the tetracycline. Tetracycline is a kind of broad-spectrum polyketide antibiotics produced by the Streptomyces genus of antinobacteria. It is a kind of bacteriostatic antibiotics which inhibits the bacteria growth through binding to the 30 S ribosomal subunit, blocking the aminoacyl tRNA from binding to the translating ribosome, thus interfering with the protein synthesis process.
Tetracycline hydrochloride is a broad-spectrum antibiotic with bactericidal activity at high concentrations. In addition to common Gram-positive and Gram-negative bacteria and anaerobic bacteria, most rickettsiae, mycoplasma, chlamydia, atypical mycobacteria, spirochetes, actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium difficile and Nocardia spp. are sensitive to this product. It is more effective against Gram-positive than Gram-negative bacteria, but Enterococcus spp. and penicillin-resistant gonococci are resistant to it. It has good antibacterial activity against Vibrio, Brucella, Campylobacter, Yersinia and other Gram-negative bacteria, but not against Pseudomonas aeruginosa.
Function of Tetracycline
It is used for the treatment of infections occurring in urinary tracts, respiratory tract, and the intestines. Because of the problem of drug resistance, tetracycline is not a frequent choice for treating bacterial infections. However, it is still used for the treatment of infections caused by chlamydia, Rickettsia and Spirochetal.
Tetracycline hydrochloride is an antibiotic used for the treatment of non-bacterial infections such as chlamydial infections, rickettsial disease, mycoplasma pneumonia and regressive fever, but also for the treatment of brucellosis, cholera, rabbit fever, rat bite fever, anthrax, tetanus, plague, actinomycosis, gas gangrene and respiratory, bile duct and urinary tract infections and skin soft tissue infections caused by sensitive bacteria.
Application of Tetracycline
The first choice for the treatment of non bacterial infection of Chlamydia, Rickettsia, mycoplasma pneumonia disease, relapsing fever and other infections, but also for the treatment of brucellosis, cholera, tularemia, rat bite fever, anthrax, tetanus, plague, actinomycosis, gas gangrene and sensitive bacterial respiratory system, bile duct, urinary tract infection and skin and soft tissue infection etc.
The mechanism of action of tetracycline hydrochloride is mainly to prevent the binding of aminyl groups to ribonucleoprotein bodies, preventing the growth of peptide chains and protein synthesis, thus inhibiting the growth of bacteria, and also having a bactericidal effect at high concentrations. There is cross-resistance between this product and oxytetracycline. It is mainly used clinically for bacillary dysentery, trachoma, whooping cough, pneumonia, septic meningitis, skin infections and otitis media.
Product Functions&Applications:
1. This product has a certain antibacterial effect on some anaerobes, but it is far inferior to metronidazole, clindamycin and chloramphenicol, so it is not used clinically. Over the years, due to the extensive application of tetracyclines, Gram-negative bacteria such as Staphylococcus and gram-negative bacilli, such as Staphylococcus, have been extensively drug-resistant to tetracycline.
Moreover, there are cross resistance among the species of the same kind. The action mechanism of this product is that the drug can specifically bind to the A location of the ribosomal 30S subunit, and prevent the binding of aminoyl tRNA on this site, thereby inhibiting the growth of peptide linkage and affecting the protein synthesis of bacteria.
2. The first choice for the treatment of non bacterial infection of Chlamydia, Rickettsia, mycoplasma pneumonia disease, relapsing fever and other infections, but also for the treatment of brucellosis, cholera, tularemia, rat bite fever, anthrax, tetanus, plague, actinomycosis, gas gangrene and sensitive bacterial respiratory system, bile duct, urinary tract infection and skin and soft tissue infection etc.
| Item | Standard | Result | ||||
| Identification | A:B:C The positive reaction. | Conforms | ||||
| Solubility | Very soluble in water, insoluble in acone , corm, ether. | Conforms | ||||
| Specific optical rotation | +53.5°~ +59.0° | +58.0° | ||||
| Acidity of alkalinity | 5.0~7.5 | 6.7 | ||||
| Impurity A | 2%max | Conforms | ||||
| Impurity C | 3% ~15% | Conforms | ||||
| Any other impurity | not more than the area of the principal peak | Conforms | ||||
| Total other impurity | not more than 3times the area of the principal peak | Conforms | ||||
| in the chromatogram obtained with RS(B)15% | ||||||
| Disregard limit | ae of the principal peak in the chromatogram | Conforms | ||||
| obtained with RS(C)1% | ||||||
| Loss on drying (pct) | max8.0 | 5.0% | ||||
| Sulphate | 27.0-31.0% | 28.4%max | ||||
| Sulphated ash | 1% max | 0.2% | ||||
| Microcount limit test | NMT 500 col/g | 10 col/g | ||||
| Microcount-yeast and molds | NMT 10 col/g | Conforms | ||||
| Assay | ≥680I.U./mg (DRY) | 687I.U./mg DRY 653I.U./mg MOIST | ||||
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