Cas:35607-66-0 Cefoxitin powder
product name |
Cefoxitin |
cas number |
35607-66-0 |
apperance |
white powder |
Density |
1.6±0.1 g/cm3 |
MF |
C16H17N3O7S2 |
MW |
427.452 |
Cefoxitin, the chemical name is 3-carbamoyloxymethyl-7-methoxy-7-(2-thiopheneacetamido)-8-oxo-5-thio-1-azabicyclo [4.2.0] Oct-2-ene-2-carboxylic acid, with the molecular formula C16H17N3O7S2, is a cephamycin antibiotic. It is a new type of antibiotic made by semi-synthesis of Cephamycin C produced by Streptomyces Lactamdurans. Its core is similar to cephalosporins and has similar antibacterial properties. It is customarily included in the second-generation cephalosporins. The mechanism of cefoxitin's antibacterial action is to inhibit the synthesis of the cell wall of active bacterial cells by binding to one or more penicillin binding proteins (PBPs) of bacterial cells, thereby exerting an antibacterial effect.
Physical and chemical properties
Appearance and properties: white to off-white crystalline powder
Density: 1.63 g/cm3
Melting point: 149-150ºC
Boiling point: 843.4ºC at 760 mmHg
Refractive index: 1.692
Storage conditions: low-temperature, ventilated and dry warehouse
The antibacterial spectrum includes Escherichia coli, Pneumoniae, Indole-positive Proteus and Serratia, Klebsiella, Influenzae, Salmonella, Shigella, etc. It also has a good effect on Staphylococcus and a variety of Streptococcus. It is mainly used clinically for respiratory tract infections, endocarditis, peritonitis, pyelonephritis, urinary tract infections, sepsis and bone, joint, skin and soft tissue infections caused by sensitive bacteria.