product name |
Lomefloxacin |
cas number |
98079-51-7 |
apperance |
white powder |
Density |
1.3±0.1 g/cm3 |
MF |
C17H19F2N3O3 |
MW |
351.348 |
English name: lomefloxacin
English alias: Lomefloxacinum; LFLX; Lomefloxacine; Maxaquin; Lomefloxacino;
MDL number: MFCD00214312
RTECS number: VB1997500
PubChem number: 24278514
Molecular formula: C17H19F2N3O3
Molecular weight: 351.34800
Accurate quality: 351.13900
PSA: 74.57000
LogP: 2.18970 [1]
Physical and chemical properties
Appearance and properties: off-white to yellow crystals
Density: 1.342 g/cm3
Melting point: 239-240ºC
Boiling point: 542.7ºC at 760 mmHg
Flash point: 282ºC
Refractive index: 1.547
Stability: Stable if stored at recommended conditions.
Storage conditions: -20ºC [1]
Toxicological data
Acute toxicity 50 mice (mg/kg): 245.6 intravenous injection; >4000 orally. [2]
Molecular structure data
1. Molar refractive index: 86.66
2. Molar volume (cm3/mol): 265.6
3. Isotonic specific volume (90.2K): 698.4
4. Surface tension (dyne/cm): 47.8 [2]
5. Polarizability (10-24cm3): 34.35
Computational chemistry data
1. Hydrophobic parameter calculation reference value (XlogP): none
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond acceptors: 8
4. Number of rotatable chemical bonds: 3
5. Number of tautomers: none
6. The polar surface area of topological molecules 72.9
7. Number of heavy atoms: 25
8.Surface charge: 0
9. Complexity: 586
10. Number of isotope atoms: 0
11.Determine the number of atomic stereo centers: 0
12. Uncertain the number of atomic stereo centers: 1
13.Determine the number of chemical bond stereo centers: 0
14. Uncertain the number of chemical bond stereo centers: 0
15.Number of covalent bond units: 1
It is a long-acting quinolone oral antibacterial drug. It exerts antibacterial effect by inhibiting bacterial DNA gyrase and stopping the growth of bacteria. It has broad antibacterial spectrum, high efficiency, safety, stable metabolism and good tolerance. Because it has no cross effect with theophylline, it is not contraindicated for patients with asthma, so it is especially suitable for the elderly. It can be used for respiratory infections, sepsis, enteritis, urinary tract infections, gynecological infections, eye and oral infections, and can also prevent infections after surgery.