CAS 79350-37-1 Pure 99% Powder Bulk Price Cefixime

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >98%
• Model NO.: cefixime
• Name: Cefixime
• Mf: C16h15n5o7s2
• CAS: 79350-37-1
• Transport Package: Drum
• Specification: 99%
• Trademark: HS
• Origin: China
• HS Code: 2904201000
• Production Capacity: 100000

Product Description

product name	Cefixime
cas number	79350-37-1
apperance	white powder
Density	1.9±0.1 g/cm3
MF	C16H15N5O7S2
MW	453.450

Cefixime (Cefixime) is a third-generation cephalosporin antibiotic for oral use. It is suitable for the treatment of respiratory, urinary and biliary infections caused by sensitive bacteria. Cefixime is highly stable to β-lactamase produced by gram-negative bacilli. Its antibacterial effect on gram-negative bacilli is stronger than that of the first and second-generation cephalosporins, and its antibacterial effect on gram-positive cocci is not as good as that of the first and second-generation cephalosporins. The second generation cephalosporin.

Use for :            

1. Respiratory system infection, such as bronchitis, pneumonia, etc.;

2. Urinary system infection, such as pyelonephritis, cystitis, urethritis, etc.;

3. Biliary tract infections, such as cholecystitis and cholangitis;

4. Others, such as otitis media, sinusitis, scarlet fever, etc
 

Cefixime is an antibiotic useful to treat a number of bacterial infections.This includes otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and Lyme disease. For gonorrhea typically only one dose is required. In the United States it is a second line treatment to ceftriaxone for gonorrhea.It is taken by mouth.

Common side effects include diarrhea, abdominal pain, and nausea.Serious side effects may include allergic reactions and Clostridium difficile diarrhea. It is not recommended in people with a history of a severe penicillin allergy.It appears to be relatively safe during pregnancy.It is in the third generation cephalosporin class of medications. It works by disrupting the bacteria's cell wall resulting in its death.

Cefixime was patented in 1979 and approved for medical use in the United States in 1989. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.It is not available as a generic medication in the United States.^[8] The wholesale cost in the developing world is about US$0.26-2.09 per dose. In the United States a course of treatment costs about $100-200 as of 2015.

Medical uses

Cefixime treats infections of the:
Ear: Otitis caused by Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes.
Sinuses: Sinusitis.
Throat: Tonsillitis, pharyngitis caused by Streptococcus pyogenes.
Chest and lungs: Bronchitis, pneumonia caused by Streptococcus pneumoniae and Haemophilus influenzae.
It is also used to treat typhoid fever.^[10]

Spectrum of bacterial susceptibility

Cefixime is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary tract, and upper respiratory tract. The following represents MIC susceptibility data for a few medically significant microorganisms:^[11]

• Escherichia coli: 0.015 µg/mL - 4 µg/mL
• Haemophilus influenzae: ≤0.004 µg/mL - >4 µg/mL
• Proteus mirabilis: ≤0.008 µg/mL - 0.06 µg/mL

Mechanism of action

The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Absorption
Only 40-50% is absorbed from the GI tract (oral bioavailability). Absorption may be decreased when taken with food. Average peak concentration after administration of oral suspension is approximately 25-50% greater than the peak concentration following oral tablet or capsules administration.

Distribution
It has high concentrations in bile and urine. It can cross the placenta and its protein binding capacity is 65%.^{[medical citation needed]}

It is always better to perform appropriate cultures and susceptibility studies to determine the causative organism and its sensitivity to cefixime.

Packaging and transportation 
Packing: this product is double-packed: the inner layer is sealed with edible polythene plastic bags, and the outer packaging is in cardboard boxes.The net content of each case is 25kg. It can also be packed according to customers' needs.

Transportation: light loading and unloading.Prevent the sun, rain, can not be mixed with toxic, harmful goods, this product is not dangerous goods, can be transported according to the general chemicals.
Storage: it should be stored in a dry, clean and dark environment. It is strictly prohibited to mix with toxic substances to avoid pollution.The shelf life is two years.