cas:58001-44-8 Clavulanate powder
| product name |
Clavulanate |
| cas number |
58001-44-8 |
| apperance |
white powder |
| Density |
1.7±0.1 g/cm3 |
| MF |
C8H9NO5 |
| MW |
199.161 |
Clavulanic acid, etc. belong to the irreversible competitive β-lactamase inhibitor, which can inactivate the enzyme after being firmly bound to the enzyme, so it has a strong effect. It not only acts on the β-lactamase of Staphylococcus aureus, but also on The β-lactamase of Negative bacilli also has an effect. The combination of penicillins and cephalosporins greatly improves the antibacterial activity, and can significantly reduce the minimum inhibitory concentration (MIC). The drug can increase the effect several times to ten times, so that the drug-resistant strains can restore their sensitivity. This product is also called clavulanic acid, a new oxygen-containing nucleus β-lactam antibiotic produced by Streptomyces. Potassium clavulanate is needle-like crystals and is easily soluble in water.
Clavulanic acid is a broad-spectrum inhibitor. It is effective against β-lactamase produced by gram-positive bacteria (such as Staphylococcus aureus) and type I, II, IV and type V β-lactamase produced by gram-negative bacteria. Strong inhibitory effect, but weak inhibitory effect on type I cephalosporinase.
Clavulanic acid can broaden the antibacterial spectrum of antibiotics intolerant to β-lactamase, such as penicillin G, ampicillin, amoxicillin or cephalosporin II (cephalotin), and enhance the antibacterial activity, and it can produce β-lactamase. -Endophthalaminase bacteria produce obvious synergistic effects, such as Staphylococcus aureus, Escherichia coli, Pneumoniae, Proteus mirabilis, Proteus vulgaris, Influenza bacillus and Fragile bacillus, etc. However, there is no synergistic effect on amoxicillin or ceftizidine-sensitive bacteria in combination with clavulanic acid.
Clavulanic acid alone is not effective. The enzyme is irreversibly inactivated by being firmly combined with β-lactamase, which protects penicillin or cephalosporin antibiotics that are not resistant to enzymes from being destroyed, so that the latter enters the site of action more and exerts its antibacterial effect. Overcome bacterial resistance to improve curative effect.
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