25122-41-2 High Purity 99% Clobetasol Propionate

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001
• State: White Powder
• Purity: >99%
• CAS: 25122-46-7
• Model NO.: Clobetasol propionate
• Mf: C25h32clfo5
• Einecs No.: 246-634-3
• Shelf Life: 24 Months
• Storage: Cool Dry Place
• MW: 466.97
• Transport Package: 1kg/Bag, 25kg/Drum
• Specification: Clobetasol propionate
• Trademark: HNB
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

Product Name	Clobetasol propionate
CAS No.	25122-46-7
MF	C25H32ClFO5
Molecular Weight	466.97
EINECS No.	246-634-3
Melting point	195.5-1970C
Boiling point	569.0±50.0 °C(Predicted)
Density	1.1653 (estimate)
Storage	-20°C Freezer
Solubility	Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).
Appearance	White powder
Package	Alum. Foil bag/barrel/OEM
Acidity coefficient (pKa)	12.88±0.70(Predicted)

 

What is Clobetasol Propionate

Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and
psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class
I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and
emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, lichen sclerosus, and lichen planus.
 

 

Function of Clobetasol Propionate

1. Anti-inflammatory effects: The product can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance.

2. Immunosuppressive effect: preventing or inhibiting cell-mediated immune response, delayed hypersensitivity reactions, reducing T lymphocytes, monocytes, eosinophils, reducing immunoglobulin binding to cell surface receptors and inhibition of the synthesis and release of interleukin, thus reducing the T lymphocyte transformation of lymphoblastoid cells, and reduce the extension of the primary immune response. Can reduce immune complexes through the basement membrane, and can reduce the concentration of ingredients complement and immunoglobulins.
 

Item	Specification	Result
Appearance	White to cream, crystalline powder	White crystalline powder
Identification (by IR)	Conforms to the CRS spectrum	Conforms
Melting Point	Approximately 196 °C	196°C
Specific rotation	+98°~+104°(dried substance)	+99.7°
Loss on drying	≤2.0%	0.002
Residue on ignition	≤0.1%	0.0006
Heavy metals	≤20ppm	Conforms
Related substance (by HPLC)	Any impurity ≤1.0% Total impurities ≤2.0%	0.0022 0.0031
Assay(by HPLC)	Contains 97.0% to 102% of C25H32CIFO5 calculated on dried basis	0.999
Residual solvents	Ethanol ≤3000ppm	262ppm
	Aceton ≤500ppm	Undetected(LOD 4ppm)
	Pyriding ≤100ppm	Undetected(LOD 3ppm)
	N,N-Dimethylformamide ≤100ppm	Undetected(LOD 10ppm)