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Lipoic acid, with the molecular formula C8H14O2S2, is an organic compound that can be used as a coenzyme to participate in acyl transfer in the metabolism of substances in the body, and can eliminate free radicals that lead to accelerated aging and disease. Lipoic acid enters cells after being absorbed in the intestines in the body, and has both fat-soluble and water-soluble properties.
As a coenzyme, lipoic acid plays a role in two key oxidative decarboxylation reactions, namely, in the pyruvate dehydrogenase complex and the α-ketoglutarate dehydrogenase complex, catalyzing the generation and transfer of acyl groups. Lipoic acid can accept an acyl group with the acetyl group of pyruvate to form a thioester bond, which then transfers the acetyl group to the sulfur atom of the coenzyme A molecule. The dihydrolipoamide that forms the prosthetic group can be oxidized by dihydrolipoamide dehydrogenase (requiring NAD+) to regenerate oxidized lipoamide. Alpha-lipoic acid contains a disulfide five-membered ring structure, with high electron density, significant electrophilicity and the ability to react with free radicals, so it has antioxidant properties, high health care functions and medical value (such as anti-oxidant). fatty liver and lowering plasma cholesterol). In addition, the sulfhydryl group of lipoic acid is easy to undergo redox reaction, so it can protect the sulfhydrylase from the toxicity of heavy metal ions.
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English name: lipoic acid CAS No.: 62-46-4 (racemic); 1200-22-2 (R); 1077-27-6 (S); Molecular formula: C8H14O2S2 Molecular weight: 206.326 Exact Mass: 206.04400 PSA: 87.90000 LogP: 2.78510 |
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