Anti-Cancer Effect API Material 99% Taxol

• Customization: Available
• Certification: RoHS, BRC, ISO, FDA, HACCP
• Assay Method: HPLC-MS, GPC, HPLC, UV
• Model NO.: Taxol
• State: Powder
• CAS: 510-36-0
• Mf: Taxus Chinensis Extract
• MW: 853.906
• Extraction Type: Solvent Extraction
• Appearance: Almost White Powder
• Storage: Cool Dried Storage
• Shelf Life: 24month
• Transport Package: 1kg/Bag, 25kg/Drum
• Specification: 99%
• Trademark: HNB
• Origin: China
• Production Capacity: 1000kg/Month

Product Description

 

Product name	Taxol	Payment	Western Union, Alibaba Trade Assurance or TT
Appearance	white powder	Delivery	By Couriers (DHL, FEDEX, EMS or TNT) or By Air
Specs	99%	Lead Time	Within 3~5days
CAS	33069-62-4	Package	Aluminum foil bag, Paperdrum or Cartons

Taxol/ Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it 'taxol'. When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to 'paclitaxel' and the BMS compound is sold under the trademark 'TAXOL'. In this formulation, paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane.

Function

Taxol/  Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis. Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes .

Application

Taxol/Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes.

Tests	Standards		Results
Appearance	white powder		Wcrystalline powder.hite,
Identification	A:IR absorption	Complies	Complies
	B:UV absorption	Complies	Complies
	C:TLC	Complies	Complies
Melting point	168~172°C		169.0~170.9°C
Water	Not more than0.5%		0.09%
Related substance	ImpurityJ(chloroacetanilide)not more than 10 ppm		2ppm
	Impurity K(4-aminophenol)not more than 50 ppm		16 ppm
	Impurity F(4-nitrophenol)not more than 0.05%		Not detected
	any other impurity not more than 0.05%		0.01%
	Total of other impurities not more than 0.1%		0.02%
Residue on ignition	Not more than 0.1%		0.05%
Chloride	Not more than 0.014%		Less than 0.014%
Sulfate	Not more than 0.02%		Less than 0.02%
Sulfide	Conforms		Conforms
Heavy metals	Not more than 0.001%		Less than 0.001%
Free p-aminophenol	Not more than 0.005%		Less than 0.005%
Limit of P-chloroacetanilide	Not more than 0.001%		Less than 0.001%
Readily carbonizable substances	Conforms		Conforms
Residual solvents	Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5%		0.08%
Assay(anhydrous basis)	99.0~101.0%		99.4%
Conclusion:   Complies with USP34/ BP2011