CAS 22832-87-7 Powder Miconazole Nitrate Miconazole

• Customization: Available
• Varieties: Parasite Disease Prevention Medicine
• Component: Animal
• Model NO.: Miconazole
• Pharmacodynamic Influential Factors: Animal Species
• Storage Method: Prevent High or LowTemperature
• Veterinary Reg. No.: 09853
• Product: Miconazole
• Mf: C18h15cl4n3o4
• CAS: 22832-87-7
• Transport Package: Drum
• Specification: 99%
• Trademark: HS
• Origin: China
• HS Code: 2904201000
• Production Capacity: 100000

Product Description

Product name: Miconazole nitrate
Appearance:White powder
CAS:  22832-87-7

MF:C18H15Cl4N3O4

EINECS No: 245-256-6

Molecular weithgs:479.14

Test method:HPLC

Purity:99%

Shelf life:2 years
Storage:Keep in cool dry place.
 

Miconazole nitrate is a kind of antifungal agent which is the drug "Dakelin" which we are familiar with as commonly used drugs for treating skin ringworm. It has various kinds of effects. It inhibit the biosynthesis of ergosterol which is the fungal cell membrane component, causing damage to the cell membrane structure, increasing the membrane permeability, resulting in the leakage of the intracellular components and inhibiting the glucose utilization, preventing the nutrient uptake, and finally leading to fungal cell death. It is therefore suitable for the treatment of tinea, jock itch, ringworm, athlete's foot, tinea versicolor and paronychomycosis as well as the vaginal infection and secondary infection caused by the yeast (such as Candida) and Gram-positive bacteria. It is also effective in treating otitis externa and bacterial skin infections. 

Product description:

 Miconazole nitrate is an antifungal agent.This product can inhibit the growth of most fungi at the concentration of 4mg/L, blastomyces and histoplasmacyces are highly sensitive to it, Cryptococcus, Candida, Coccidiococcus are also sensitive to this product.By interfering with the activity of cytochrome P-450, it can inhibit the biosynthesis of ergosterol, the main sterol in the fungal cell membrane, and damage the fungal cell membrane and change its permeability, so that important intracellular substances leak out.It can also inhibit the biosynthesis of fungal triacylglycerol and phospholipids, inhibit the activity of oxidase and peroxidase, and cause the accumulation of hydrogen peroxide in cells, leading to cell submicrostructure degeneration and cell necrosis.Candida albicans can inhibit its transformation from spore to invasive hyphae.

 
Function & Application

Miconazole is an imidazole antifungal agent, commonly applied topically to the skin or to mucus membranes to cure fungal infections. It can also be used against certain species of Leishmania protozoa which are a type of unicellular parasite that also contain ergosterol in their cell membranes. In addition to its antifungal and antiparasitic actions, it also has some limited antibacterial properties.

 

Product name	Miconazole nitrate
CAS No	22832-87-7	Outer Packing	25KG drum
Production date	2015.05.01	Shelf life	2018.04.30
Standard adopted	USP34/BP2011
Items of analysis	Specification		Results
Characteristics	White or white crystalline powder		Complies
Identification	Infrared absorption and standard		Complies
Solution clarity	Solution is clear, color is not deep in the standard Y7		Complies
Solubility	Difficult to dissolve in water, soluble in ethanol, slightly soluble in ethanol		Complies
Optical rotation	-0.1°-+0.1°		0°
Singleimpurity	≤0.25%		0.18%
Total impurity	≤0.5%		0.32%
Melting Point	178-194ºC		182.7-183.9ºC
Loss On Drying	≤0.5%		≤0.5%
Sulfate ash	≤0.1%		0.09%
Ethanol	≤600ppm		100ppm
Assay(On Dry Basis	99.3%		99.3%
Conclusion	Qualified