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Polymyxins B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxins B is composed of a number of related compounds.It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic peptides that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin.
English name: polymyxin B CAS Number: 1404-26-8 EINECS Number: 215-768-4 Molecular formula: C43H82N16O12 Molecular weight: 1189.45000 Exact mass: 1188.73000 PSA: 490.66000 LogP: 1.73180 Boiling point: 1651ºC at 760 mmHg Flash point: 952.3ºC |