API Raw Materials CAS 58-33-3 Promethazine HCl Hydrochlorine HCl Powder

• Customization: Available
• CAS No.: 58-33-3
• Formula: C17h21cln2s
• Model NO.: Hydrochlorine
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Colour: White
• Name: Hydrochlorine HCl
• Mf: C17h21cln2s
• CAS: 58-33-3
• MOQ: 1kg
• Transport Package: Drum
• Specification: 99%
• Trademark: HNB
• Origin: China
• HS Code: 29323324
• Production Capacity: 500000

Product Description

API Raw Materials cas 58-33-3 Promethazine hcl hydrochlorine hcl powder

Product name	Promethazine Hcl
Cas number	58-33-3
Apperance	White Powder
MF	C17H21ClN2S
MW	320.879

 
Promethazine hydrochloride is a kind of organic matter, the chemical formula is C17H20ClN2S, is a common cough antihistamine, is an antihistamine, can competitionally block the histamine H1 receptor, against the histamine-induced telangiectasis, and reduce its permeability.Therefore, it can calm down the cough caused by irritation of the trachea.
Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.
Promethazine hydrochloride is used as antihistamine; antiemetic; central nervous system depressant; sedative; anticholinergic; antiserotoninergic; local anesthetic; in the treatment of motion sickness, cough linctuses, nausea, and allergic conditions; used to control Parkinsonian symptoms and as central nervous system depressant; in pills, syrup, injections and suppositories.