| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product name | Griseofulvin |
| CAS | 126-07-8 |
| Appearance | white powder |
| Assay | 99% |
| Storage | Cool and Protect from light |
Description:
Griseofulvin is a nonpolyene class antifungal antibiotics; it can strongly inhibit the mitosis of fungal cell and interfere with the fungal DNA synthesis; it can also bind to tubulin to prevent fungal cell division. It has been applied to clinical medicine since 1958 and has currently been widely used for treating the fungal infections of the skin and the stratum corneum with strong inhibitory effects on Trichophyton rubrum and Trichophyton tonsorans, etc. Griseofulvin is not only a widely used antibiotic for clinical treatment of fungal infections of the skin and cuticle, but also applied in agriculture for prevention and treatment of fungal diseases; for example, it has a special efficacy on treating a kind of candidiasis in apple which can cause infection during pollination.
The main function of Griseofulvin is to treat fungal infections, particularly those caused by dermatophytes, a type of fungi that commonly infects the skin, hair, and nails. It is effective against a range of fungal infections, including ringworm, jock itch, athlete's foot, and fungal infections of the scalp andnails.
Griseofulvin works by binding to the fungal cell wall and disrupting its structure, preventing the fungi from reproducing and spreading. It is most effective when taken for a prolonged period of time, as it can take several weeks or months to completely eliminate the fungal infection.
While Griseofulvin is primarily used to treat fungal infections, it has also been investigated for its potential use in the treatment of other conditions, such as cancer and autoimmune diseases. However, more research is needed to fully understand its effects in these areas.
Overall, Griseofulvin is an antifungal medication that is used to treat a variety of fungal infections of the skin, hair, and nails. Its main function is to inhibit the growth of fungi and prevent them from reproducing, allowing the body to eliminate the infection.
| Test Item | Specification | Result |
| Appearance | White or almost white crystalline powder | White crystalline powder |
| Identification | Complies | Complies |
| PH | 4.0~5.5 | 4.8 |
| Water | 4.0%~8.0% | 5.60% |
| Specific Optical Rotation (anhydrous substance) |
+149° ~+158° | +156.0° |
| Absorbance at 330nm | ≤ 0.05 | 0.012 |
| Absorbance at 262nm (anhydrous substance) |
220-245 | 231.9 |
| Assay(anhydrous substance) | 95.0%~102.0% | 99.8% |
| Related Substances Impurity B Any Other Impurity Total |
≤ 1.0% ≤ 1.0% ≤ 3.0% |
0.00 0.04 0.12 |
| Sulphated Ash | ≤ 0.2% | 0.02% |
| N, N-Dimethylaniline | Not more than 20ppm | Not detected |
| Appending Item Bulk Density (g/ml) Tapped Density (g/ml) |
---- ---- |
0.56 0.79 |
| Conclusion: This batch complies with the specification | ||
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