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5-Fluorouracil, This product is the most commonly used uracil antimetabolite. It first undergoes a series of reactions in the body into fluorouracil deoxynucleotides, and then exerts its effect (affecting DNA synthesis); it can still be converted into fluorouracil in vivo and incorporated into RNA, thereby Interferes with protein synthesis. The main effect is in the S phase, but it also has a certain effect on cells in other phases. It is easy to pass through the blood-brain barrier, and it is easy to enter the brain tissue and tumor metastases. About 10% to 30% of the prototype is excreted in the urine, and about 60% to 80% is inactivated in the liver into CO2 and urea, which are excreted through the respiratory tract and urine respectively. This product has a broad anti-tumor spectrum
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English name: 5-Fluorouracil CAS Number: 51-21-8 Molecular formula: C4H3FN2O2 Molecular weight: 130.08 MDL number: MFCD00006018 No. Beilstein: 127172 EINECS Number: 200-085-6 Melting point: 282-286ºC |