| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Domperidone is a dopamine blocker and an antidopaminergic reagent.Target: Dopamine ReceptorDomperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets [1]. Domperidone is a dopamine D(2) receptor antagonist, which has been used as antiemetic agent in human beings. The percentage recovery of domperidone from wastewater was 95.0%. Celiprolol was used as the internal standard to access the percentage extraction of domperidone from wastewater [2]. Domperidone, a dopamine antagonist that does not easily cross the blood-brain barrier, is considered the gold standard for treating gastrointestinal symptoms in patients with Parkinson's disease (PD) because the risk of developing extrapyramidal adverse effects is considered minimal.
Domperidone is a benzimidazole compound that has strong stomach-stimulating and antiemetic effects, can strengthen the lower esophageal sphincter tension, prevent gastric-esophageal reflux, enhance gastric motility, promote gastric emptying, and coordinate the stomach with the twelve-finger Intestinal exercise, inhibition of nausea, vomiting, and effective prevention of bile reflux, does not affect the secretion of gastric juice.
Application
1.Domperidone is used for the treatment of gastroparesis (especially diabetic gastro-light gastroparesis), which can eliminate the symptoms of gastric retention and shorten the gastric emptying time; patients with moderate to moderate functional dyspepsia (FD) It can completely eliminate or significantly reduce symptoms such as abdominal distention, epigastric pain, belching, early satiety, nausea, and vomiting after meals.
2.Domperidone has a significant effect on reflux gastritis, but it is not very satisfactory for the efficacy of reflux esophagitis.
3.Domperidone can be used as an adjunctive treatment for peptic ulcers (mainly gastric ulcers) to eliminate antral retention.
Nausea and vomiting .There is some evidence that domperidone powder has antiemetic activity.
Domperidone powder may be useful in diabetic and idiopathic gastroparesis.
Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease,
Domperidone may be used in functional dyspepsia in both adults and children.
Application
It can be against pests with fast contact and stomach poison effect on the leaves have a strong infiltration under the skin can kill pests, Vinca longer, for some pests have some ovicidal action. The suction effect can effectively control Lepidoptera, Diptera and Thysanoptera pests, but also a good prevention Coleoptera and Lepidoptera feeding on leaves of some large number of pest species, sucking pests and mite's prevention less effective. On insect predators safer, because insecticidal unique mechanism of action. Suitable for vegetables, fruit, horticulture, crop use. Insecticidal effect was less affected by the rains.
| Test Item | Specification | Results |
| Appearance | White to off white powder | White powder |
Solubility |
Practically insoluble in water, soluble in dimethylformamide, | Confirms |
| slightly soluble in ethanol(96%) and in methanol | ||
Identification |
A. M.P. 244~248ºC | 244.5~245.5ºC |
| B. IR should comply | Confirms | |
| C. TLC should comply | Confirms | |
| D. It gives the reaction of non-nitrogen substituted barbiturates. | Confirms | |
Clarity of solution |
The solution is clear and not more intensely colored than | Confirms |
| reference solution Y6 | ||
Related substance |
Total impurities≤0.5% | ≤0.29% |
| Individual impurity≤0.25% | ≤0.18% | |
| Loss on drying | ≤0.5% | 0.07% |
| Sulphated ash | ≤0.1% | ≤0.05% |
| Heavy metal | ≤20ppm | <20ppm |
| Assay | 99.0%~101.0% | 99.49% |
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