Veterinary Medicine Raw Material Powder Antibiotic CAS 55297-96-6 Tiamulin Fumarate

• Varieties: Growth Promoting Medicine
• Component: Animal
• Type: The First Class
• Pharmacodynamic Influential Factors: Animal Species
• Storage Method: Prevent ThrowIing Expired Veterinary Drugs
• Veterinary Reg. No.: 692-813-8
• Model NO.: Tiamulin Fumarate
• Name: Tiamulin Fumarate
• Mf: C32h51no8s
• CAS: 55297-96-6
• Shelf Time: 2 Years
• Transport Package: Drum
• Specification: 99%
• Trademark: HNB
• Origin: China
• HS Code: 29323324
• Production Capacity: 500000

Product Description

Veterinary Medicine Raw Material Powder Antibiotic CAS 55297-96-6 Tiamulin Fumarate

Product Name	Wholesale Veterinary Antibiotic Medicine Raw Material Purity Tiamulin Fumarate Powder CAS 55297-96-6
Appearance	white powder
cas	55297-96-6
Assay	99%
Keywords	Purity Tiamulin Fumarate;Tiamulin Fumarate Powder;Tiamulin Fumarate Antibiotic Medicine
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

 
What is Tiamulin Fumarate?

Tiamulin fumarate is awhite or white crystalline powder, odourless, tasteless, chicken for chronic respiratory disease, swine and hemophilus pleura pneumonia mycoplasma pneumonia,  

CAS number:55297-96-6
Tiamulin hydrogen fumarate is a derivative of pleuromutilin, can be used in veterinary medicine particularly for pigs and poultry.It is a diterpene antimicrobial with a pleuromutilin chemical structure similar to that of valnemulin.
Tiamulin hydrogen fumarate is white or almost white crystalline powder, odorless and tasteless. It is easily soluble in methanol or ethanol, soluble in water, slightly soluble in acetone, and almost insoluble in hexane . 
This product is a bacteriostatic antibiotic, but it also has bactericidal effect on sensitive bacteria at very high concentration. The antibacterial mechanism of action is to inhibit bacterial protein synthesis by binding to the 50s subunit of the bacterial ribosome.
Tiamulin hydrogen fumarate has good antibacterial activity against a variety of Gram-positive cocci, including most staphylococci and streptococci (except group D streptococci) and a variety of mycoplasmas and some spirochetes. However, the antibacterial activity against some negative bacteria is very weak, except for Haemophilus species and some E. coli and Klebsiella strains.
Tiamulin hydrogen fumarate is easy to be absorbed after oral administration in pigs. About 85% of a single dose is absorbed, and peak concentrations occur in 2 to 4 hours. It is widely distributed in the body, with the highest concentration in the lungs. Tiamulin hydrogen fumarate is metabolized in the body into 20 metabolites, some with antibacterial tranquility. About 30% of the metabolites are excreted in the urine and the remainder is excreted in the feces.
 

Tiamulin is a semi-synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity. The hemi-fumarate provides a stable salt with improved water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action of inhibiting protein synthesis by binding to domain V of 23S rRNA.


Application

Tiamulin is mainly used to prevent and cure chicken chronic respiratory disease, Mycoplasma pneumoniae (asthma), actinomycosis and Treponema. Low dose can promote growth and improve feed utilization.

Usage:Tiamulin hydrogen fumarate is used for the treatment of swine pneumonia caused by Actinobacillus pleuropneumoniae and swine blood dysentery caused by Treponema hyodysenteriae. As a feed drug additive for pigs can promote weight gain. It is also effective against chronic respiratory disease in chickens, mycoplasma hyopneumonia, and staphylococcal synovitis in chickens.
Content:≥ 98%
Packing: 25kg/cardboard drum
Preparations: 10%, 45% 80% Tiamulin hydrogen fumarate premix / soluble powder

TEM	SPECIFICATION	METHOD REFERENCE
Appearance	white powder	Visual
Ammonium	≤200ppm	USPmonograph
Chloride	≤200ppm	USP35<221>
Sulfate	≤300ppm	USP35<221>
Iron	≤10ppm	USP35<241>
Arsenic	≤2ppm	USP35<211>
Heavy metals	≤10ppm	USP35<231>Method I
Loss on drying(3h at 105 ºC)	≤0.5%	USP35<731>
Residue on Ignition	≤0.1%	USP35<281>
Total impurities	≤2.0%	USP monograph
Assay(dry basis)	98.0% to 101.0%	USP monograph