Apis High Purity CAS No 15307-79-6 Diclofenac Potassium Diclofenac Sodium

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >96%
• Model NO.: Diclofenac sodium
• Name: Diclofenac Sodium
• Mf: C14h10cl2nnao2
• CAS: 15307-79-6
• Transport Package: Drum
• Specification: 99%
• Trademark: HS
• Origin: China
• HS Code: 2904201000
• Production Capacity: 100000

Product Description

Description of Diclofenac Sodium

 

Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite  4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy  diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble

amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.

What is Diclofenac sodium ?
Diclofenac Sodium is a Non-steroidal anti-inflammatory drugs have a rapid onset of action, and produce analgesic, anti-inflammatory and anti-pyretic effects mainly by inhibiting the synthesis of prostaglandins.
Diclofenac sodium is an NSAID that is used to treat inflammation and pain, mostly those associated with arthritis.

Diclofenac Sodium  Function
1. Treat inflammation and pain, mostly those associated with arthritis.
2. Post-traumatic pain and inflammation, such as sprains, muscle strains, etc.;
3. Severe otolaryngological infection pain and inflammation (such as tonsillitis, otitis, sinusitis, etc.) should be combined with anti-infective drugs.

Item	Standard	Test Result
Characteristic	Pure white crystalline powder, slightly hygroscopic	Conforms
Solubility	Sparingly soluble in water, freely soluble in	Comforms
	methanol, ethanol (96%); slightly soluble in acetone;
	practically insoluble in ether
Identify	(A) IR-Spectrum	(A)conforms
	(B) Reaction of sodium salt	(B)Positive
PH	6.5~7.5	7.13
Appearance of solution	Clear	Conforms
	Absorption of sodium salt≤0.05	0.015
Related substances	Single impurity ≤0.2%	Conforms
	Total impurity ≤0.5%
Heavy metal	≤10ppm	Conforms