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Trimethoprim, referred to as TMP, is an organic compound with the chemical formula C14H18N4O3, which is a white or light yellow crystalline powder, odorless and bitter in taste.
Trimethoprim is a bacterial dihydrofolate reductase inhibitor and a sulfonamide synergist. The principle of its antibacterial effect is to interfere with the folic acid metabolism of bacteria. It is mainly to selectively inhibit the activity of bacterial dihydrofolate reductase, so that dihydrofolate cannot be reduced to tetrahydrofolate, thereby inhibiting the growth and reproduction of bacteria.
Trimethoprim is a synthetic broad-spectrum antibacterial agent, used alone for respiratory infections, urinary tract infections, intestinal infections and other diseases, and can be used to treat sepsis, meningitis, otitis media, typhoid fever, shigellosis ( Bacillary dysentery) etc.
Foreign name Trimethoprim Chemical formula C14H18N4O3 Molecular weight 290.318 Appearance white or off-white crystalline powder CAS accession number 738-70-5 EINECS accession number 212-006-2 Density 1.252 g/cm³ Melting point 199 to 203 ºC |