| Customization: | Available |
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| Powder: | Yes |
| Customized: | Non-Customized |
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| Product name | Agomelatine |
| Cas No. | 138112-76-2 |
| Molecular Formula | C15H17NO2 |
| Appearance | White powder |
Agamelatine is a melatonin receptor agonist (MT1 and MT2 receptors) and 5-HT2C receptor antagonist. Animal studies have shown that agomelatine can correct the circadian rhythm in animal models with circadian rhythm disturbance, so that the circadian rhythm can be reconstructed.
Agomelatine has shown antidepressant effects in a variety of animal models of depression.The mechanism of antidepressant may be related to the increase of neuronal plasticity and neuronal proliferation in hippocampus.
Immunostaining was used to measure the proliferation, regeneration and death of nerve cells in the brain of adult rats. It was found that long-term (3 weeks) administration of agomelatine increased the proliferation and regeneration of neurons in the ventral dentate gyrus of the hippocampus, which is involved in emotional response.No similar effect was observed at acute or subacute administration (4 h or 9 weeks).
After prolonged administration, the whole dentate gyrus region showed cell proliferation and neuronal regeneration, suggesting that agomelatine can increase the nerve regeneration in hippocampus to some extent, thus generating new granulosa cells.
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