Pharmaceutical cas 64-86-8 Autumn Crocus Extract Powder USP/Ep 99% Colcemid Colchicine
| Product name: Colchicine |
| Other Name:Natural Colchicum Autumnale Extract |
| Appearance:Light Yellow powder |
| CAS:64-86-8 |
| M.F.:C22H25NO6 |
| M.W.:399.44 |
| Specification:99% |
What is Colchicine?
Colchicine is one of a group of macrocyclic alkaloids. Chemical formula: C22H23NO6. It is commonly found in the liliaceae plants of Jialan and Lijiangshan, with the content of 0.11% and 0.1%, respectively. Alkaloids, extracted from the plant colchicine, inhibit the formation of spindle filaments and thus delay the division of the centromere.
Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as "meadow saffron").Adverse effects are primarily gastrointestinal upset at high doses.In addition to gout, colchicine is used to treat familial Mediterranean fever, pericarditis, and Behçet's disease.
Colchicine is a natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, Colchicum autumnale, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition. In neurons, axoplasmic transport is disrupted by colchicine.
Function:
1> It is anti-gout, anti-tumor, inhibiting the mitotic cell stopping in M phase.
2> It has the significant effects on breast cancer, cervical cancer, esophageal cancer, lung cancer,Gastric cancer and chronic myelogenous leukemia.
3> It also can be used for acute gout, anti-inflammatory analgesic.
4> In recent years, furtherly expand its clinical application, for example: To prevent atherosclerosisDamage; To cure the liver cirrhosis; To relief the cycle heat caused by abnormal catecholamine,The Behcet's disease; The lumbar disc herniation, intractable waist pain and sciatica;Prevent intestine adhesion.
5> In addition, its used as the treatment of Purple epilepsy caused thrombocytopenia;Persistent apophysis erythema; Advanced schistosomiasis;
6> Moreover, using colchicine three can get the polyploidy, so Colchicine is indispensable in chromosome research.
Explanation:
1> Light yellow crystal. smellless, will change dark yellow when exposed to the light.
2> Solubility :1g Colchicine solved in 22ml water, in 220ml aethers or 100ml benzene ,
sparing soluble in alcohols and chlform. Insoluble in petroler.
3> Optical rotation -250° (c=1, alcohol)
| Analysis |
Specification |
Results |
| Assay(HPLC) |
Colchicine ≥99% |
99.5% |
| Appearance |
White fine powder
|
Complies |
| Moisture |
≤5.0% |
1.2% |
| SpecifiºC Rotation |
-248.4° |
-240°~-250° |
| Heavy metals |
≤20ppm |
Complies |
| Pb |
≤1.0ppm |
Complies |
| As |
≤1.0ppm |
Complies |
| Cd |
≤0.05ppm |
Complies |
| Hg |
≤0.05ppm |
Complies |
| Odor |
Characteristic |
Complies |
| Particle size |
100%through 80 mesh |
Complies |
| Microbioiogical |
| Total of bacteria |
≤1000cfu/g |
Complies |
| Fungi |
≤100cfu/g |
Complies |
| Salmgosella |
Negative |
Complies |
| Coli |
Negative |
Complies |
Storage Store in cool & dry place. Do not freeze.
Keep away from strong light and heat.
Shelf life 2 years when properly stored |
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