| Customization: | Available |
|---|---|
| CAS No.: | 77-09-8 |
| Formula: | C20h14o4 |
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| Product Name | Phenolphthalein |
| CAS No. | 77-09-8 |
| Molecular Formula | C20H14O4 |
| Molecular Weight | 318.32 |
| Appearance | White Powder |
| Assay | 99% |
| Grade | Pharmaceutical Grade |
Phenolphthalein is a chemical that is commonly used as a colorimetric pH indicator. The compound has been observed to turn orange at pH <0, clear between pH 0-8.2, fuchsia between pH 8.2-12, and clear again at a pH above 12. It has been postulated that the mutagenic effects of Phenolphthalein at high doses can be attributed the enhancement intracellular free oxygen radicals. The compound has also been observed to induce mitotic abnormalities and micronuclei with kinetochores in vitro. In Syrian hamster embryos treated with 10-40 μM of Phenolpthalein a significant number of chromosomal aberrations occurred at the hprt locus. On human breast cancer cells Phenolphthalein has been observed to have weak estrogenic effects.
Uses: acid-base indicator, chromatography reagents, organic synthesis, pharmaceutical industry (such as the manufacture of laxatives)
Fuction&Application of Phenolphthalein
Classification
Digestive system drugs> Promote diarrhea drugs
Pharmacological effects
Phenolphthalein irritating laxatives, the main role in the large intestine. After oral administration in the intestinal alkaline environment to
form soluble sodium salt, stimulate the plexus wall plexus, a direct role in the intestinal smooth muscle, so that peristalsis increased.
At the same time phenolphthalein and inhibit intestinal absorption of water, so that water and electrolyte accumulation in the colon,
resulting laxation effect. The role of strength and intestinal size of alkaline, and its role in mild, rarely cause intestinal spasm.
Pharmacokinetics
Phenolphthalein after oral 6 ~ 8h effect. About 15% of oral absorption after absorption of drugs mainly in the form of glucuronide by the
kidneys or excretion of excreted, some can also be excreted to the intestine by the bile, was reabsorbed in the intestine to form enterohepatic
circulation, thereby prolonging the duration of action , So the role of a single administration of sustainable 3 to 4 days. Unabsorbed part is
excreted via feces. Phenolphthalein can also be secreted by milk.
Indications
1 for habitual intractable constipation.
2. In the colon, rectal endoscopy or X-ray examination for cleaning the intestine.
Contraindications
1. Allergic to phenolphthalein.
2. Baby
3. Appendicitis
4. Rectal bleeding is not diagnosed.
5. Congestive heart failure.
6. Hypertension.
7. Intestinal obstruction.
8. Renal insufficiency.
9. fecal blockage.
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TEST ITEM |
SPECIFICATION |
RESULTS |
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Characteristics |
A white or almost white powder, practically insoluble in water, soluble in alcohol. |
A white powder, practically insoluble in water, soluble in alcohol. |
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Melting Point |
It melts at about 260°C. |
261ºC.~262ºC. |
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Identification |
A:Positive B:Positive |
A:Positive B:Positive |
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Appearance of solution |
The solution is clear and not more intensely coloured than reference solution Y7 |
Complies |
|
Related substances |
Less than 0.5% |
<0.5% |
|
Heavy metals |
Not more than0.001% |
<0.001% |
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Acidity or alkalinity |
Complies |
Complies |
|
Chlorides |
Not more than 0.01% |
<0.01% |
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Sulphates |
Not more than 0.02% |
<0.02% |
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Loss on drying |
Not more than 0.5% |
0.12% |
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Sulphated ash |
Not more than 0.1% |
0.01% |
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Assay |
98.0%-101.0%(C20H14O4) |
99.6% |
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CONCLUSION: Conform With EP6/BP2009 |
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