CAS 9041-08-1 Heparin Sodium

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001
• State: White Powder
• Purity: >99%
• CAS: 9041-08-1
• Model NO.: Heparin Sodium
• Mf: (C12h16ns2na3)20
• Shelf Life: 24 Months
• Storage: Cool Dry Place
• Transport Package: 1kg/Bag, 25kg/Drum
• Specification: Heparin Sodium
• Trademark: HNB
• Origin: China
• HS Code: 3002200000
• Production Capacity: 2000kg/Month

Product Description

Product Name	Heparin Sodium
Alias	Ardeparin Sodium,Nadroparine Sodium
CAS	9041-08-1
EINECS	232-681-7
MF	(C12H16NS2Na3)20
Grade	Pharmaceutical Grade
Appearance	White Powder

 

Heparin sodium salt, used as an anticoagulant, is a mucopolysaccharide substance, is the sodium salt form of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle, and sheep. It is secreted by mast cells to be naturally presented the blood inside the human bodies. Heparin can prevent platelet aggregation and destruction, inhibit the conversion from fibrinogen to fibrin monomers, inhibit the formation of thromboplastin and fight against the pre-formed thromboplastin, and also prevent the conversion of prothrombin to thrombin and counteract the antithrombin.


Heparin sodium salt can delay or prevent blood coagulation in vitro and in vivo. Its mechanism of action is very complicated which involves many processes of coagulation process. Its role is to: 1. inhibit the formation and function of thromboplastin, thus preventing the conversion of prothrombin into thrombin; 2. Inhibit the thrombin and other coagulation factors at relative high concentrations, preventing the conversion of fibrinogen to fibrous proteins; 3. prevent platelet aggregation and destruction. In addition, the anticoagulant effect of Heparin sodium salt is still related to the negatively charged sulfate inside its molecule. Positively charged alkaline substance such as protamine or toluidine blue can all neutralize its negative charge, thus inhibiting its anticoagulant effect. Because heparin can be activated in vivo and release lipoprotein lipase, hydrolyzing the triglycerides and low-density lipoprotein in chylomicrons, so it also has a lipid-lowering effect.

 

TEST  ITEMS		SPECIFICATIONS	TEST  RESULTS
Characters		WHITE 0R WHITE LIKE  POEDER	Complies
Solubility		Freely soluble in water	Complies
Identificatin		A; Delay of cloting of recalcified cimated sheep plasma. B;1H-NMR Spectrum; Comply with the EP speacification of heparin about 1H-NMR requiremenls. C; The principal peak in the chromatogram obtained with test solution is similar in retention time and shape to the principal peak in the chromatogram obtained with reference solution. D; Positive sodium reaction.	Complies Complies   Complies     Complies
pH		5.5~8.0	6.6
Realated substances		A:Sum of dermantan sulfate and chondroitin sulfate:≤2.0% B:Any other impurity Free	Complies Complies
Appearance of solution		A:5%w/v solution is clear and colourlesss B:Solution is not more inicnscly coloured than reference solution BY5 or better	Complies Complies
Heavy metals		≤30ppm	Complies
Loss on drying		≤8.0%	1.4%
Protein		≤0.5%	0.07%
Nitrogen		1.5%~2.5%	2.2%
Sodium		9.5%~12.5%	12.1%
Sulphated ash		28%~41.0%	37.3%
Nueleotide impurlties		260nm≤0.15	260n 0.07
Microbial contamination		A: Total viable acrobic count: max.10 CFU/g B;Fung yeasts: max. 10 CFU/g C; Specified micro orgnisms Escherichina coli Salmonclla Pscudomonas aeruginosa	10 CFU/g 10 CFU/g   Negative Negative Negative
Residual solvents		Ethanol: Not more than 5000 ppm	955ppm
Bacterial endotoxins		0.01IU/IU of heparin	Complies
Impurlfy (NMR)		The N-acetyl protons of heparin show a single peak at 2.04±0.02ppm No peak should be visible at 2.16±0.03ppm	Complies
POTENCY		≥180 u/mg	194 u/mg
CONCLUSl0N	CONFORH T0 THE REQUIREMENT OF EP7.0 STANDARD