CAS 50-33-9 Sodium Butazolidine Phenylbutazone

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  • CAS 50-33-9 Sodium Butazolidine Phenylbutazone
  • CAS 50-33-9 Sodium Butazolidine Phenylbutazone
  • CAS 50-33-9 Sodium Butazolidine Phenylbutazone
  • CAS 50-33-9 Sodium Butazolidine Phenylbutazone
  • CAS 50-33-9 Sodium Butazolidine Phenylbutazone
  • CAS 50-33-9 Sodium Butazolidine Phenylbutazone
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Basic Info.

Model NO.
Phenylbutazone
Certification
GMP, ISO 9001, USP, BP
Suitable for
Adult
State
Solid
Purity
>98%
Product Name
Phenylbutazone
Mf
C19h19n2nao2
CAS
50-33-9
Transport Package
Drum
Specification
99%
Trademark
HS
Origin
China
HS Code
2904201000
Production Capacity
100000

Product Description

CAS 50-33-9 Sodium Butazolidine Phenylbutazone

Name: Phenylbutazone
CAS: 50-33-9
MF: C19H20N2O2
MW: 308.37
Standard: EP4 / USP32
Purity: Pharmaceutical grade 99%
Appearance: white powder
chemical properties: It is soluble in acetone, chloroform or benzene freely; soluble in ethanol or ether; hardly soluble in water; soluble in sodium hydroxide solution.

 

Phenylbutazone is a nonsteroidal anti-inflammatory, antipyretic, and analgesic drug (NSAID) for the short-term treatment of pain and fever results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis.

Phenylbutazone is used in rheumatoid arthritis, rheumatoid arthritis and gout. Often need continuous administration or interaction with other drugs. For filariasis acute lymphangitis. The role of similar aminopyrine. However, antipyretic analgesic effect is weak, while the strong anti-inflammatory effect of inflammatory pain better. Can promote uric acid excretion.
Phenylbutazone is a role in the central nervous system drugs, is a pyrazolone derivatives, antipyretic
analgesic effect is weak and strong anti-inflammatory effect on the inflammatory pain, and can promote
the excretion of uric acid.

 

Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.

CAS 50-33-9 Sodium Butazolidine Phenylbutazone

Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, It is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable.

In horses

Phenylbutazone is the most commonly used NSAID for horses in the United States. It is used for the following purposes:

Analgesia: It is used for pain relief from infections and musculoskeletal disorders, including sprains, overuse injuries, tendinitis, arthralgias, arthritis, and laminitis. Like other NSAIDs, it acts directly on musculoskeletal tissue to control inflammation, thereby reducing secondary inflammatory damage, alleviating pain, and restoring range of motion. It does not cure musculoskeletal ailments or work well on colic pain.

Antipyresis: It is used for reduction of fevers. Its antipyretic qualities may mask other symptoms; therefore, it should not be administered for this purpose unless a veterinarian has concluded the horse would not be able to eat or drink without its use or that the fever might hinder the horse's recovery.

 

What is Phenylbutazone?

Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.Target: OthersPhenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, when combined with paracetamol and many other household painkillers even in the smallest doses can cause irreversible liver degradation proving fatal in many cases. It is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable.Phenylbutazone may be administered orally (via paste, powder or feed-in) or intravenously. It should not be given intramuscularly or injected in any place other than a vein, as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein. Phenylbutazone should be administered only under the advice of a veterinarian.

CAS 50-33-9 Sodium Butazolidine Phenylbutazone

TEST

SPECIFICATIONS

RESULTS

CHARACTERS

 

A WHITE OR ALMOST WHITE, CRYSTALLINE POWDER

COMPLIES

 

IDENTIFICATION

A.IR  B.UV

    COMPLIES

UV SPECTRUM

A(1%,1cm)MAXIMUM(650-700)AT 264nm

COMPLIES

IR ABSORPTION

SAME BANDS THE STANDARD

COMPLIES

MELTING RANGE

104 ~ 107°C

104 ~ 107°C

HEAVY METALS

≤0.001%

COMPLIES

LOSS ON DRYING

≤0.5%

0.05%

RESIDUE ON IGNITION

≤0.1%

0.05%

CHLORIDE

≤0.007%

COMPLIES

SULPHATE

≤0.01%

COMPLIES

RESIDUAL SOLVENTS

METHANOL≤0.3%

ETHANOL≤0.5%

N.D

COMPLIES

ORGANIC VOLATILE IMPURITIES

COMPLIES

COMPLIES

ASSAY

99.0~102%

99.86%

STORAGE

STORE PROTECTED FROM LIGHT AND AIRTIGHT-NOT EXCEEDING 25°C

CAS 50-33-9 Sodium Butazolidine PhenylbutazoneCAS 50-33-9 Sodium Butazolidine PhenylbutazoneCAS 50-33-9 Sodium Butazolidine PhenylbutazoneCAS 50-33-9 Sodium Butazolidine PhenylbutazoneCAS 50-33-9 Sodium Butazolidine PhenylbutazoneCAS 50-33-9 Sodium Butazolidine Phenylbutazone

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