Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Phenylbutazone is a nonsteroidal anti-inflammatory, antipyretic, and analgesic drug (NSAID) for the short-term treatment of pain and fever results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis.
Phenylbutazone is used in rheumatoid arthritis, rheumatoid arthritis and gout. Often need continuous administration or interaction with other drugs. For filariasis acute lymphangitis. The role of similar aminopyrine. However, antipyretic analgesic effect is weak, while the strong anti-inflammatory effect of inflammatory pain better. Can promote uric acid excretion.
Phenylbutazone is a role in the central nervous system drugs, is a pyrazolone derivatives, antipyretic
analgesic effect is weak and strong anti-inflammatory effect on the inflammatory pain, and can promote
the excretion of uric acid.
Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.
What is Phenylbutazone?
Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.Target: OthersPhenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, when combined with paracetamol and many other household painkillers even in the smallest doses can cause irreversible liver degradation proving fatal in many cases. It is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable.Phenylbutazone may be administered orally (via paste, powder or feed-in) or intravenously. It should not be given intramuscularly or injected in any place other than a vein, as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein. Phenylbutazone should be administered only under the advice of a veterinarian.
TEST |
SPECIFICATIONS |
RESULTS |
CHARACTERS
|
A WHITE OR ALMOST WHITE, CRYSTALLINE POWDER |
COMPLIES
|
IDENTIFICATION |
A.IR B.UV |
COMPLIES |
UV SPECTRUM |
A(1%,1cm)MAXIMUM(650-700)AT 264nm |
COMPLIES |
IR ABSORPTION |
SAME BANDS THE STANDARD |
COMPLIES |
MELTING RANGE |
104 ~ 107°C |
104 ~ 107°C |
HEAVY METALS |
≤0.001% |
COMPLIES |
LOSS ON DRYING |
≤0.5% |
0.05% |
RESIDUE ON IGNITION |
≤0.1% |
0.05% |
CHLORIDE |
≤0.007% |
COMPLIES |
SULPHATE |
≤0.01% |
COMPLIES |
RESIDUAL SOLVENTS |
METHANOL≤0.3% ETHANOL≤0.5% |
N.D COMPLIES |
ORGANIC VOLATILE IMPURITIES |
COMPLIES |
COMPLIES |
ASSAY |
99.0~102% |
99.86% |
STORAGE |
STORE PROTECTED FROM LIGHT AND AIRTIGHT-NOT EXCEEDING 25°C |