• Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir
  • Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir
  • Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir
  • Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir

Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir

Powder: Yes
Customized: Non-Customized
Certification: GMP, ISO 9001, USP, BP
Suitable for: Elderly, Children, Adult
State: Solid
Purity: >99%
Samples:
US$ 5/Gram 1 Gram(Min.Order)
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Customization:
Diamond Member Since 2021

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Rating: 5.0/5
Manufacturer/Factory

Basic Info.

Model NO.
HNB-280
Transport Package
Aluminium Foil Bag, Cardboard Drum
Trademark
HNB-Biotech
Origin
Shaanxi, China
Production Capacity
500kg/Month

Product Description

Synthetic anti-infective drugs CAS 192725-17-0 Lopinavir
Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir

Synthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir
Product name Lopinavir
Cas No. 192725-17-0
Molecular Formula C37H48N4O5
Appearance White powder

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM.Target: HIV proteaseLopinavir is a potent inhibitor of Rh123 efflux in Caco-2 monolayers with IC50 of 1.7 mM. Lopinavir exposure (72 hours) in LS 180V cells reduces the content of intracellular Rh123. Lopinavir induces P-glycoprotein immunoreactive protein and messenger RNA levels in LS 180V cells. Lopinavir inhibits subtype C clone C6 with IC50 of 9.4 nM. Lopinavir inhibits CYP3A with IC50 of 7.3 mM in human liver microsomes, while produces negligible or weak inhibition of human CYP1A2, 2B6, 2C9, 2C19 and 2D6. Lopinavir (10 mg/kg, orally) results in Cmax of 0.8 μg/mL and oral bioavailability of 25% in rats.Synthetic Anti-Infective Drugs CAS 192725-17-0 LopinavirSynthetic Anti-Infective Drugs CAS 192725-17-0 LopinavirSynthetic Anti-Infective Drugs CAS 192725-17-0 LopinavirSynthetic Anti-Infective Drugs CAS 192725-17-0 LopinavirSynthetic Anti-Infective Drugs CAS 192725-17-0 LopinavirSynthetic Anti-Infective Drugs CAS 192725-17-0 LopinavirSynthetic Anti-Infective Drugs CAS 192725-17-0 Lopinavir
 

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