Veterinary raw material powder Levamisole Hydrochloride Levamisole
| Product name |
Levamisole Hydrochloride |
CAS: |
16595-80-5 |
| |
|
MF |
C11H13ClN2S |
Levamisole Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives.IC50 value: Target: Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform . It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging.
Use As an anthelmintic, it is suitable for the treatment of animal aphids, hookworms, etc.
Use This product is an anthelmintic drug. The activity of levamisole is about twice that of the racemate, and the toxicity and side effects are also low. Levamisole can paralyze the aphid muscles and excrete with the feces. Mainly used for anti-aphids and anti-hookworms.
How does Levamisole HCL work?
How does Levamisole HCL work as an antiparasitic agent?
Levamisole HCL is absorbed through the gut, can also be absorbed through the skin and is distributed throughout the body.
Levamisole affects the neurotransmitters and paralyzes the worm (spastic paralysis). The fish then passes the inactive worms. Good gravel vacuuming is advised after treatment to remove the paralyzed (but still live) worms.
It is not ovicidal, which means it will not affect eggs already present, but it will affect the larval stage of the worm. To ensure complete eradication of the parasite treat again after remaining eggs have hatched.
How does Levamisole HCL work as an immunomodulator?
The mechanism of action for its immunostimulating effects are not well understood. It is believed that it restores cell-mediated immune function in peripheral T-lymphocytes and stimulates phagocytosis by monocytes.
The drug appears to restore depressed immune function rather than to stimulate
response to above-normal levels. There are multitudes of medical studies being done with its use in humans and animals, the goal being to attain understanding of its immunomodulating mechanism. The mechanism will be defined, with time.
However, at the time of the writing of this article, there is no complete answer to this question. For us, it is enough to know that it does stimulate immune function in fish that are suffering due to parasites or
disease.
Veterinary Drugs Levamisole CAS 14769-73-4 Application:
1) Levamisole is a broad spectrum anthelmintic, it is mainly used for expelling worms and hook worms.
2) Levamisole was originally used as an anthelmintic to treat worm infestations in both humans and animals.
3) Furthermore,Levamisole can be used to autoimmune diseases such as rheumatoid arthritis, lupus erythematosus and on the flu, and children's respiratory infection, hepatitis, dysentery, sore throat problems, such as abscess. Right obstinate bronchial asthma, as a preliminary trial prove significant effect.
| Items |
Specification |
Results |
| Characters |
White or almost white crystalline power |
White crystalline power |
| Identification |
Positive |
Positive |
| Appearance of solution |
Complies |
Complies |
| PH |
3.0~4.5 |
3.8 |
| Specific optical rotation |
-121°~-128° |
-124.2° |
| Related substances |
≤0.5% |
<0.5% |
| Heavy metals |
≤20ppm |
<20ppm |
| Loss on drying |
≤0.5% |
0.08% |
| Sulphated ash |
≤0.1% |
0.01% |
| Assay |
98.5%~101.0% |
100.3% |
| Conclusion |
The quality of the above commodity complies standard of USP28 |
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