Ibuprofen (Ibuprofen), also known as isobuprofen, is a non-steroidal anti-inflammatory and analgesic drug. Its anti-inflammatory, analgesic, antipyretic effect is good, the adverse reaction is small. At present, it has been widely used in the world and has become one of the best-selling over-the-counter drugs in the world. Together with aspirin and paracetamol, it has been listed as the three pillar products of antipyretic and analgesic drugs. In China, it is mainly used in pain relief and anti-rheumatism, but not much in cold and fever, far lower than paracetamol and aspirin. Dozens of Chinese pharmaceutical companies hold the approval number for the production of ibuprofen preparations, but most of the domestic sales of ibuprofen are accounted for by "Fenbeide" sustained-release capsules produced by SmithKline in Tianjin. Ibuprofen was discovered by Dr Stephen Adams, who later became a professor and was awarded an MBE, and a team led by the scientist Coleen Burrows and the chemist Dr JohnNicholson. The aim of the initial research was to create a "super aspirin" that could lead to an alternative treatment for rheumatoid arthritis that is as effective as aspirin but has fewer serious adverse effects. Other drugs, such as bute, have a higher risk of agranulocytosis; Corticosteroids, at doses slightly higher than commonly prescribed, carry a higher risk of adrenal depression and other adverse effects such as gastrointestinal ulcers. Adams decided to look for a drug with good gastrointestinal tolerance, a property that is particularly important for all current nonsteroidal anti-inflammatory drugs. Phenyl acetate drugs have aroused interest. Although some of these drugs were found to be dangerous for ulcers in dog studies, Adams realized that this could be due to the longer half-life of the drug clearance. One compound in this class, ibuprofen, has a shorter half-life of just two hours. Of the alternatives tested, though not the most effective, they are the safest. In 1964 ibuprofen emerged as the most promising alternative to aspirin.
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