CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine

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  • CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine
  • CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine
  • CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine
  • CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine
  • CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine
  • CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine
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Basic Info.

Model NO.
cyproheptadine
Certification
GMP, ISO 9001, USP, BP
Suitable for
Adult
State
Solid
Purity
>98%
Name
Cyproheptadine Hydrochloride
Mf
C16h17n3o4s
CAS
41354-29-4
MOQ
1kg
Shelf Life
2 Years
Transport Package
Drum
Specification
99%
Trademark
HS
Origin
China
HS Code
2904201000
Production Capacity
100000

Product Description

CAS 41354-29-4 Cyproheptadine Hydrochloride Cyproheptadine HCl CyproheptadineCAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine
 
Product name Cyproheptadine Hydrochloride
CAS no. 41354-29-4
Molecular Formula C21H22ClN
Molecular Weight 323.86
Brand Name HNB

 

Description: 
Cyproheptadine is a anti-allergic agent that counteracts the effects of histamine on blood vessels and bronchial smooth muscles, thereby eliminating allergy symptoms. Cyproheptadine can be used for allergic reactions such as urticaria, eczema, allergic and contact dermatitis, and itchy skin.
Cyproheptadine (Diphenylcycloheptadine) Cyproheptadine is an anti-allergic drug that counteracts the effect of histamine on blood vessels and bronchial smooth muscle in the body, thereby eliminating allergic symptoms. Cyproheptadine can be used for allergic reactions such as urticaria, eczema, allergic and contact dermatitis, and itchy skin.

Cyproheptadine hydrochloride is also called second benzene heptyl organism, partial pain, e thyl benzene ring heptyl organism, anti root, is a kind of six hydrogen pyri dine class antihistamines, can compete with the release of histamine of H1 receptor on the effector cells, so as to prevent the onset of allergic reactions, remove the cause spasm of histamine Chemicalbook and congestion, this product has strong H1 receptor antagonist, The antihistamine effect is stronger than that of prulamine and promethazine. Have mild, moderate anti - 5- hydroxytryptamine effect and anti - choline effect. In addition, still have the action that stimulates appetite, the visible weight after taking certain time increases.
  
Cyheptadine hydrochloride is a white or yellowish crystalline powder, almost odorless and slightly bitter in taste. Soluble in me thanol, soluble in chloro form, slightly soluble in ethanol, slightly soluble in water, and almost insoluble in ether.

Clinical cyproheptadine hydrochloride is mainly used for acute or chronic urticaria (especially cold sex urticaria has fine effect), papular urticaria, angioedema, atopic eczema, contact dermatitis, food allergy, drug allergy, allergic rhinitis, hay fever, allergic conjunctival Chemicalbook inflammation, insect stings, allergy and migraine. It has certain therapeutic effect on bronchial asthma. It can also be used for the adjuvant treatment of Cushing's syndrome and acromegaly. It can also be used as an appetite enhancer for neurophobias. There are reports on the treatment of acanthosis nigricans and the prevention of pyoderma necrotizing.

It is white or light yellow crystalline powder, odorless and slightly bitter in taste. It is soluble in water, ethanol, chlororm, meanol, and almost insoluble in ether.
Pharmacology and application
Antihistamines have stronger H1 receptor antagonism than chlorpheniramine, and have mild to moderate anti-ECTkey=serotonin target=_blank>serotonin and anticholinergic effects. It can also stimulate appetite and increase weight.
Function Indication
It can be used for urticaria, eczema, allergic and contact dermatitis, skin itching, rhinitis, migraine, bronchial asthma, etc. Skin itching usually disappears within 2 to 3 days after taking the medicine. It also has a certain effect on Cushing's disease and acromegaly.

Usage and dosage
oral. Adults: 4-20 mg daily, divided into 3 to 4 times. Children: 2 to 6 years old, 2 mg each time, 2 to 3 times a day; 7 to 14 years old, 4 mg each time, 2 to 3 times a day.

CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine

(1). Cyproheptadine is used to treat allergic reactions (specifically hay fever).[6] It is also used to treat vasomotor mucosal edema, including vasomotor rhinitis and edema of the throat.
(2). It has shown effectiveness in the treatment of nightmares, including those related to post-traumatic stress disorder.
(3). It has been used in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors), and in cases of high levels of serotonin in the blood resulting from a serotonin-producing carcinoid tumor.
(4) .It can also be used as a preventive measure against migraine in children and adolescents.[15][16][17][18][19] In Australia this is the only indication for which cyproheptadine is subsidised by the PBS.
(5). It can relieve SSRI-induced sexual dysfunction and drug-induced hyperhidrosis (excessive sweating).
(6). It is also used in the treatment of cyclical vomiting syndrome;
(7).Use of the drug can stimulate the appetite and may lead to weight gain, which is helpful for underweight people.
(8).According to a small study, cyproheptadine hydrochloride has been found to improve sleep, calmness, and mood and energy levels, and to improve both negative and (sometimes even) positive psychotic symptoms in a subgroup of chronic schizophrenics who did not respond (either completely or sufficiently) to other therapies.
(9). Cyproheptadine may improve akathisia in patients on antipsychotic medications.
(10).In clinical trials in which cyproheptadine was used as an adjunct to antipsychotic treatment for patients with schizophrenia, an improvement in negative symptoms was seen.

 

Test Item Specification Result
Appearance White or almost white crystalline powder White crystalline powder
Identification Complies Complies
PH 4.0~5.5 4.8
Water 4.0%~8.0% 5.60%
Specific Optical Rotation
(anhydrous substance)
+149° ~+158° +156.0°
Absorbance at 330nm ≤ 0.05 0.012
Absorbance at 262nm
(anhydrous substance)
220-245 231.9
Assay(anhydrous substance) 95.0%~102.0% 99.8%
Related Substances
Impurity B
Any Other Impurity
Total
≤ 1.0%
≤ 1.0%
≤ 3.0%
0.00
0.04
0.12
Sulphated Ash ≤ 0.2% 0.02%
N, N-Dimethylaniline Not more than 20ppm Not detected
Appending Item
Bulk Density (g/ml)
Tapped Density (g/ml)
----
----
0.56
0.79
Conclusion: This batch complies with the specification


CAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder CyproheptadineCAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder CyproheptadineCAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder CyproheptadineCAS 41354-29-4 Cyproheptadine HCl Hydrochloride Powder Cyproheptadine

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