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Rifaximin is an organic compound with the chemical formula C43H51N3O11. It is the first non aminoglycoside intestinal antibiotic with strong efficacy and a wide antibacterial spectrum. It is highly active against Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus faecalis in Gram positive aerobic bacteria, Salmonella, Escherichia coli, Shigella, Yersinia enterocolitica, cocci in Gram negative irregular aerobic bacteria, and Bacteroidetes in Gram negative anaerobic bacteria.