Cas:51940-44-4 Pipemidic acid Antibiotic powder
| product name |
Pipemidic acid |
| cas number |
51940-44-4 |
| apperance |
white powder |
| Density |
1.4±0.1 g/cm3 |
| MF |
C14H17N5O3 |
| MW |
303.316 |
Pipemidic acid, the chemical name is 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazine)-pyridine [2,3-D] pyrimidine-6-carboxylic acid, the molecular formula is C14H17N5O3 is a medicine used for respiratory infections.
CAS Number: 51940-44-4
Molecular formula: C14H17N5O3
Molecular weight: 303.31600
Accurate quality: 303.13300
PSA: 100.35000
LogP: 0.31300 [1]
Physical and chemical properties
Appearance and properties: light yellow crystalline powder
Density: 1.38g/cm
Boiling point: 534.9ºC at 760mmHg
Flash point: 277.3ºC
Refractive index: 1.617 [1]
Security Information
Symbol: GHS08
Signal word: Danger
Hazard statement: H317; H334
Cautionary statement: P261; P280; P342 + P311
WGK Germany: 2
RTECS number: UV1153800
production method
Condensation and cyclization of 2,4-dichloropyrimidine-5-carboxylic acid ethyl ester and β-ethylaminopropionic acid ethyl ester to 2-chloro-5-hydroxy-7,8-dihydro-8-ethylpyridinepyrimidine- 6-carboxylate. Then, after bromination, it is condensed with piperazine, hydrolyzed, and neutralized to obtain pipemidic acid.
Mainly used for urinary tract, intestinal and ear canal infections caused by sensitive gram-negative bacilli and staphylococci, such as urethritis, cystitis, dysentery, enteritis, otitis media, etc.
Pipemidic acid's antibacterial activity and antibacterial spectrum are stronger and broader than nalidixic acid, but not as good as fluoroquinolones (norfloxacin, etc.); bacteria resistant to nalidixic acid may still be sensitive to this product. Pipemidic acid is indicated for sensitive bacteria (mainly Gram-negative bacilli, such as Escherichia coli, Pneumoniae, Aerobacteria, Indole-positive and indole-negative Proteus, Serratia, Typhoid, Shigella , Pseudomonas aeruginosa, etc.) caused by urinary tract infections and intestinal infections. The minimum inhibitory concentration of this product against Pseudomonas aeruginosa is 12, 5~50μg/ml, which is better than carbenicillin; generally synergistic effect can be obtained when combined with gentamicin, oxybenicillin, etc., but it is best to have combined drug sensitivity Test as a basis. Pipemidic acid has also been used to treat biliary tract infections, respiratory tract infections, trauma infections, mastitis, keratitis, etc. caused by sensitive bacteria, and has achieved certain results.
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