Oxytetracycline Hydrochloride (Oxytetracycline HCL)
CAS: 2058-46-0
EINECS: 218-161-2
MF: C22H25ClN2O9
Standard USP/BP
Properties:Yellow crystalline powder, orderless and bitter;There is moisture ;It is easy to destory and fail in alkali solution when the light color gradually fades.Soluble in water ,slightly soluble in ethanol ,insoluble in chloroform or ether.Indication antibiotics.This product is a broaspectrum bacteriostatic agent .Many rickettsia, mycoplasam,chlamydia, spirochetes, amoeba and some plasmodium parasites are also sensitive to this product, Enterococcus is resistant to it .Others, such as actinomycetes, anthrax, listeria mononucleosis, clostridium bacillus ,nucaria, vibrio, brucella, campyobacter,yersinia, etc,are sensitive to this product.
What is Oxytetracycline ?
Oxytetracycline hydrochloride, antibiotics. Alias: Methomycin, oxytetracycline. Oxytetracycline hydrochloride is a broad-spectrum bacteriostatic agent, many Rickettsia, Mycoplasma genus, chlamydia, spirochetes, amoeba protozoa and some malaria parasites are also sensitive to this product. Enterococcus is resistant to it. Other such as actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia,Vibrio, Brucella, Campylobacter,Yersinia are sensitive.
Application of Oxytetracycline
Oxytetracycline hydrochloride can be used as a drug for the following diseases:
(1) Rickettsia disease, including epidemic typhus, endemic typhus, rocky mountain fever, tsutsugamushi
disease and Q fever.
(2) Mycoplasma infection.
(3) Chlamydia infection, including parrot fever, sexually transmitted diseases, lymphoid edema,
nonspecific urethritis, salpingitis, cervicitis and trachoma.
(4) return to heat.
(5) brucellosis.
(6) Cholera.
(7) Rabbit fever.
(8) Plague.
(9) chancre.
Treatment of brucellosis and plague when combined with aminoglycosides.
As the current common pathogens resistant to oxytetracycline hydrochloride serious, only in the pathogen sensitive to the goods, can be used as a drug: the sensitive strains of Escherichia coli, Enterobacter aeruginosa, , Shigella, Haemophilus influenzae (respiratory tract infection only) and Klebsiella (limited to respiratory and urinary tract infections) and other Gram-negative bacilli infection.
Oxytetracycline hydrochloride should not be used for any type of staphylococcus or hemolytic streptococcal infection.
Oxytetracycline hydrochloride can be used for penicillin allergy to tetanus, gas gangrene, yas, syphilis, gonorrhea and leptospirosis as well as actinomycetes, Listeria infection in patients.
Oxytetracycline hydrochloride can be used for acute intestinal amebiasis and moderate to severe acne patients as adjuvant therapy.
Function of Oxytetracycline
Oxytetracycline hydrochloride is a broad spectrum of antibiotics, its antibacterial spectrum, antibacterial principle and application and tetracycline is basically the same. Many Rickettsia, Mycoplasma, Chlamydia, Spirochetes, Amoeba and some Plasmodium are also sensitive to this product. Enterococcus is resistant to it. Other such as actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia are sensitive to this product. This product has a certain antibacterial activity against Neisseria gonorrhoeae and meningococcus, but resistant to penicillin Neisseria gonorrhoeae is also resistant to oxytetracycline. Over the years due to the wide application of tetracyclines, clinical common pathogens resistant to oxytetracycline serious, including Staphylococcus aureus and other Gram-positive bacteria and most Gram-negative bacilli. There is cross-resistance between different varieties of tetracycline antibiotics. This product mechanism for the drug can specifically with the bacterial ribosome 30S subunit A position of the combination of inhibition of peptide chain growth and the impact of bacterial protein synthesis. This product on intestinal infections, including amoebic dysentery, the effect is slightly stronger than tetracycline. And tetracycline has a close cross-resistance.
| CHARACETRS: |
YELLOW CRYSTALLINE POWDER |
CONFORMS |
| IDENTIFICATION: |
TLC |
CONFORMS |
| SULPHURIC ACID REACTION A YELLOW COLOUR DEVELOPS |
CONFOMS |
| IT GIVES REACTION OF CHLORIDES |
CONFOSM |
| PH |
2.0~3.0 |
2.4 |
| SPECIFIC ABSORBANCE |
AT 349nm E(1%) 300~355 |
320 |
| SPECIFIC OPTICAL ROTATION |
-105 ~ -120° |
-110° |
| HEAVY METALS: |
≤50PPM |
< 20PPM |
| LIGHT-ABSORBING IMPURITIES |
AT 490nm ≤0.07 |
0.04 |
| RELATED SUBSTANCES |
6-EPIDOXYCYCLINE ≤2.0% |
1.80% |
| |
|
| METACYCLINE ≤2.0% |
0.10% |
| |
|
| 4-EPIDOXYCYCLINE ≤0.5% (EP5) |
NOT FOUND |
| |
|
| 4-EPI-6-EPIDOXYCYCLINE ≤0.5% (EP5) |
NOT FOUND |
Audited Supplier 
Oxytetracycline Hydrochloride (Oxytetracycline HCL)
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