Anti-Depressant 56296-78-7 Fluoxetine HCl Hydrochloride Fluoxetine

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >98%
• Model NO.: fluoxetine
• Name: Fluoxetine Hydrochloride
• CAS: 56296-78-7
• Transport Package: Drum
• Specification: 99%
• Trademark: HS
• Origin: China
• HS Code: 2904201000
• Production Capacity: 100000

Product Description

Products Name: Fluoxetine hydrochloride

Synonyms : Methyl[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amine hydrochloride; N-Methyl-gama-[4-(trifluoromethyl)

CAS No: 59333-67-4;56296-78-7

EINECS No: 260-101-2

Molecular Formula: C23H23NO4

Molecular Weight: 377.433
 
Introduction:

Fluoxetine was shown to be effective for depression in six-week-long double-blind controlled trials, where it also alleviated anxiety and improved sleep. Fluoxetine was better than placebo for the prevention of depression recurrence when the patients, who originally responded to fluoxetine, were treated for a further 38 weeks. Efficacy of fluoxetine for geriatric, as well as pediatric, depression was also demonstrated in placebo-controlled trials.

Research suggests that a significant part of the resistance to the SSRIs paroxetine (Paxil) and citalopram(Celexa) can be explained by the genetic variation of Pgp transporter. Paroxetine and citalopram, which are Pgp substrates, are actively transported from the brain by this protein. Fluoxetine is not a substrate of Pgp, and thus a switch from paroxetine or citalopram to fluoxetine may be beneficial to the nonresponders.

Application:

Fluoxetine is frequently used to treat major depression, obsessive compulsive disorder, bulimia nervosa,panic disorder, body dysmorphic disorder, premenstrual dysphoric disorder, and trichotillomania. Caution should be taken when using any SSRI for bipolar disorder as this can increase the likelihood of mania; however, fluoxetine can be used with an antipsychotic (such as quetiapine) for bipolar. It has also been used for cataplexy, obesity, and alcohol dependence,as well as binge eating disorder.

Product Name:	Fluoxetine hydrochloride
Synonyms:	(+-)-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanaminehydrochlorid;3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylaminehydrochloride;fontex;lilly110140;n-methyl-3-phenyl-3-(p-trifluoromethylphenoxy)-propylaminhydrochloride;FLUOXETINE-D5 HCL;FLUOXETINE-D5 HCL (PHENYL-D5);FLUOXETINE-D5 HYDROCHLORIDE
CAS:	56296-78-7
MF:	C17H19ClF3NO
MW:	345.79
EINECS:	260-101-2
Product Categories:	Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Serotonin;Amines;Aromatics;Isotope Labelled Compounds
Mol File:	56296-78-7.mol

Chemical Properties	White to Off-White Powder
Usage	A labelled selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.
Usage	A selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.
Usage	A selectiive derotonin reuptake inhibitor. Used as an antidepressant
Biological Activity	Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K i of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT 1A , 5-HT 2A , H 1 , α 1 , α 2 -adrenergic, and muscarinic receptors. Antidepressant. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .