Pharmaceutical Raw Material CAS 137071-32-0 Pimecrolimus Powder

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Solid
• Purity: >99%
• Model NO.: HNB-307
• Transport Package: Aluminium Foil Bag, Cardboard Drum
• Trademark: HNB-Biotech
• Origin: Shaanxi, China
• Production Capacity: 5000kg/Month

Product Description

Pharmaceutical Raw Material CAS 137071-32-0 Pimecrolimus Powder

Product name	Pimecrolimus
Cas No.	137071-32-0
Molecular Formula	C43H68ClNO11
Appearance	White powder

Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.Target: OthersPimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function. Pimecrolimus prevents the release of cytokines and pro-inflammatory mediators from mast cells. Pimecrolimus binds to macrophilin-12, the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase. The pimecrolimus-macrophilin complex prevents the dephosphorylation of the cytoplasmic component of the nuclear factor of activated T cells by inhibiting the action of calcineurin. Pimecrolimus inhibits not only the transcription and synthesis of cytokines from mast cells, but also the release of preformed mediators serotonin and β-hexosaminidase by the inhibition of Fcε-RI-mediated degranulation and secretion.