| Varieties: | General Disease Prevention Medicine |
|---|---|
| Component: | Chemical Synthetic Drugs |
| Storage Method: | Cool Dry Place |
| CAS: | 55297-96-6 |
| Mf: | C32h51no8s |
| MW: | 609.81 |
| Samples: |
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| Customization: |
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| Product Name | Tiamulin fumarate |
| CAS No. | 55297-96-6 |
| EINECS | 259-581-6 |
| MF | C32H51NO8S |
| MW | 609.81 |
| Appearance | Powder |
| Melting Point | 147-148°C |
| Loss on drying | ≤0.5% |
| Heavy Metal | ≤10ppm |
| Purity | 98% |
Introduction
Tiamulin is a semi-synthetic derivative of Pleuromutilin. It is highly active against gram-positive organisms such as streptococci, staphylococci and against mycoplasmas and serpulina (Treponema) hyodysenteriae. A number of Shigella, Klebsiella and E. coli are also quite susceptible to this agent. Some anaerobic species including Bacteroides fragilis and Clostridium perfringens with no exception are sensitive to tiamulin.
Tiamulin acts bacteriostatically. The biochemical basis for the antibacterial action is inhibition of protein synthesis, by binding to 70S ribosomes.
Tiamulin is used for prevention and control of mycoplasmal diseases such as enzootic pneumonia and chronic respiratory disease in pigs and poultry; and swine dysentery, porcine colonic spirochaetosis and porcine proliferative enteropathy.
Function
It is mainly used to prevent and cure chicken chronic respiratory disease, Mycoplasma pneumoniae (asthma), actinomycosis and Treponema. Low dose can promote growth and improve feed utilization.
|
Item |
Specification |
|
Appearance |
White or almost white crystal powder |
|
Identification |
HPLC: The retention time obtained from the test solution corresponding to that obtained from the standard solution |
|
IR: IR of the sample corresponding to that reference standard |
|
|
Color and clarity of solution |
The solution should be clear and colorless, and the absorbance at 400nm and 650nm are not greater than 0.150 and 0.030 |
|
Specific rotation |
+24~28° |
|
PH |
3.1~4.1 |
|
Loss on drying |
≤ 0.5% |
|
Melting point |
143~149°C |
|
Fumarate content |
83.7~87.3mg |
|
Residue on ignition |
≤ 0.1% |
|
Heavy metals |
≤ 0.001% |
|
Solvent residue |
≤ 0.5% |
|
Chromatographic purity |
Any identified impurity ≤ 1.0% |
|
Any unidentified impurity ≤ 0.5% |
|
|
Total impurities≤ 2.0% |
|
|
Assay (on dried basis) |
98.0~102.0% |
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