| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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| Product Information | |
| Name | Isoniazid |
| Assay | 99% |
| Appearance | White crystalline powder |
| Package | 1kg/carton; 25kg/drum |
| Payment | Alipay; Western Union; TT |
| Shipment | DHL; FedEx, EMS; Air; Sea |
| Standard | USP/EP/CP/BP |
| Storage | Sealed in dark and dry place |
| Shelf Life | 3 Years |
What's Isoniazid?
Isoniazid is an antibacterial agent used primarily as a tuberculostatic. Target: Antibacterial Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing. |
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Application & Function of Isoniazid 1.Antituberculosis inhibits and kills Mycobacterium tuberculosis. Its biomembrane permeability is good. Because of its good curative effect, low toxicity, low cost, and convenience for oral administration, it is listed as the first choice antituberculosis drug.
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