| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | GMP, ISO 9001, USP, BP |
| Suitable for: | Adult |
| State: | Solid |
| Purity: | >99% |
| Samples: |
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| Customization: |
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Audited Supplier 
| Product Name: | Microcrystalline cellulose |
| Cas No | 9004-34-6 |
| MF | (C6H10O5)n |
| EINECS | 232-674-9 |
| Purity | Not less than 97% of carbohydrate calculated as cellulose on the dried basis |
| Color | white microcrystalline powder |
What is Microcrystalline Cellulose ?
Microcrystalline cellulose (C6H10O5)n is refined wood pulp. It is a white, free-flowing powder. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In large quantities it provides dietary bulk and may lead to a laxative effect.
Microcrystalline cellulose is a commonly used excipient in the pharmaceutical industry. It has excellent compressibility properties and is used in solid dose forms, such as tablets. Tablets can be formed that are hard, but dissolve quickly. Microcrystalline cellulose is the same as cellulose, except that it meets USP standards.
It is also found in many processed food products, and may be used as an anti-caking agent, stabilizer, texture modifier, or suspending agent among other uses. According to the Select Committee on GRAS Substances, microcrystalline cellulose is generally regarded as safe when used in normal quantities.
Microcrystalline Cellulose Uses .
Filler: Fillers are mandatory for tablet manufacturing where the doses of drugs are very low. MCC can be used for all types of tablet making processes like direct compression, wet granulation, and dry procession.
Direct Compression: MCC is used as an excipient in direct compression. It has high dilution capacity and higher active ingredient carrier capacity. It has the potential to hold itself together even under direct compression. Another reason for its popularity is the low bulk density; it will lead to high dilution and packing density. It helps in producing tablets with better hardness levels and less fragile. It also provides superior white color and provides stability.
Wet granulation: As mentioned earlier it has insoluble properties at the same time it is hydrophilic. Hence, it is preferred choice for this manufacturing process. The benefit of using MCC is that can retain water, it further helps in uniform granulation. Case solidifying is a process saw in deficiently dried granules. Now and again, when the granules are dried at a high temperature, within the granules stay wet also; the surface appears to be dried. MCC is useful as it is less sensitive to wet mass, therefore, it does not get over wet, dries faster, you will find fewer case hardening and disintegrates quickly.
Roller Compaction: Roller compaction is a dry procedure including compaction of materials into strips that are at that point processed to produce a granulation. This granulation is then greased up and packed on a tablet machine. Usage of MCC in this manufacturing process improves in compaction, flow enhancement, and content uniformity.
Binder: To gain the appropriate mechanical strength and give volume to the smaller active ingredient dose, binders are very helpful. It affects the quality and appearance of the tablet. Considering the hydrophyllic water wicking qualities of MCC, it is widely used as a binder in the pharmaceutical industry.
Disintegrant: MCC is broadly utilized as a disintegrant in dry compressions also, wet granulation systems. It improves tranquilize disintegration by speeding tablet deterioration, gives the largest amount of breaking down power at low utilize levels, and uses double breaking down instruments of wicking and swelling for more quick breaking down.
Since its presentation, MCC has totally adjusted the pharmaceutical research situation making altogether new levels of assembling efficiencies.
Packages and Storage
Package: 1kg/bag, 25kgs/paper drum or according to your request.
Storage: In Tight, Light-resistant and Dry Place. Avoid Direct Sunshine.
|
Items |
Specifications |
Results |
|
Characteristic |
White or almost white |
Almost white powder
|
|
pH |
3.5 ~ 6.0 |
4.5 |
|
Crystallinity |
Conforms |
Conforms |
|
Water |
11.5% ~ 14.5% |
12.8% |
|
Assay (on the anhydrous basis) |
900~1050 μg/mg |
981μg/mg |
|
Tapped density |
≥0.70g/ml |
0.81g/ml |
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